ArticleMedical science monitor : international medical journal of experimental and clinical research2021
Factors Influencing Sodium Valproate Serum Concentrations in Patients with Epilepsy Based on Logistic Regression Analysis.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Personalized prediction of initial valproic acid dose in children with epilepsy using machine learning techniques.International journal of clinical pharmacy · 2026Article
- Ensemble Machine Learning Model for Real-Time Valproic Acid Prediction in Epilepsy Treatment.Pharmacopsychiatry · 2026Article
- Article
- Development and validation of a clinical nomogram for predicting suboptimal concentration of valproate in pediatric with epilepsy: a retrospective study.Frontiers in pharmacology · 2026Article
- The study of promoting the rational use of sodium valproate in the intensive care unit.Scientific reports · 2025Article
- A Clinical Nomogram for Predicting Substandard Serum Valproic Acid Concentrations in Chinese Patients With Epilepsy.Current therapeutic research, clinical and experimental · 2025Article
- Factors influencing valproic acid trough levels in epileptic children.La Tunisie medicale · 2024Observational
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
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Abstract
BACKGROUND We aimed to explore the risk factors that affect the serum concentration of sodium valproate (VPA-Na) in patients with epilepsy and to provide references for the rationale of the use of VPA-Na. MATERIAL AND METHODS The enzyme-multiplied immunoassay technique was used to determine the serum VPA-NA concentrations of 109 patients, and the results were retrospectively analyzed and summarized. A multivariate logistic regression model was used to analyze substandard serum VPA-Na concentrations. RESULTS Fifty-six patients (51.38%) treated with VPA-Na tablets were within the effective treatment range of 50-100 μg/mL, while 53 patients (48.62%) were out of the treatment range. The results indicated that the standard-reaching rate of serum drug concentration in the juvenile group was higher than that in the adult and elderly groups; the standard-reaching rates of serum drug concentrations in the low-dose group and the intermediate-dose group were lower than that in the high-dose group; and the standard-reaching rate of serum drug concentration in the group receiving carbapenems in combination was lower than that in the non-combination group; all differences were statistically significant. The combination with carbapenems and enzyme inducers was an independent risk factor for VPA-Na serum concentration below the target level in hospitalized patients. CONCLUSIONS To improve clinical efficacy and reduce the occurrence of adverse reactions, there is a need for therapeutic drug monitoring of VPA-Na. Moreover, individual administration should be implemented when VPA-Na tablets are used in the treatment of epilepsy because of the significant fluctuation in VPA-Na blood concentration.
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