Evidence map›Paper›PMID 34776482›Full record

ArticleInternal medicine (Tokyo, Japan)2022

The Efficacy of Amenamevir for the Treatment of Disseminated Herpes Zoster Complicated with Probable Varicella-zoster Pneumonia in an Immunocompromised Patient.

Hiroki Kobayashi, Yusuke Yoshida, Tomoki Komoshita, Harumichi Suma, Yohei Hosokawa, Yoshikazu Hirose, Tomohiro Sugimoto, Sho Mokuda, Shintaro Hirata, Eiji Sugiyama

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Hiroki KobayashiDepartment of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Japan.
Yusuke YoshidaDepartment of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Japan.
Tomoki KomoshitaPostgraduate Clinical Training Center, Hiroshima University Hospital, Japan.
Harumichi SumaDepartment of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Japan.
Yohei HosokawaDepartment of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Japan.
Yoshikazu HiroseDepartment of Dermatology, Hiroshima University Hospital, Japan.
Tomohiro SugimotoDepartment of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Japan.
Sho MokudaDepartment of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Japan.
Shintaro HirataDepartment of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Japan.
Eiji SugiyamaDepartment of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Japan.
Hiroshima University Hospital · JPNational Hospital Organization · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We herein report the case of a 78-year-old woman who was diagnosed as having disseminated herpes zoster (DHZ) complicated with probable varicella-zoster pneumonia during maintenance therapy for microscopic polyangiitis. Because the patient had severe renal dysfunction, amenamevir administration was started to avoid any neurotoxicity of acyclovir, which is suggested to be optimal for treatment. It ameliorated her symptoms without any adverse events. This is the first report suggesting the efficacy of amenamevir in the treatment of severe herpes zoster infection with coexisting DHZ and probable varicella-zoster pneumonia. Amenamevir could thus be a treatment option for severe varicella zoster virus infections.

Indexed as

ChickenpoxHerpes ZosterPneumoniaVaricella Zoster Virus InfectionAcyclovirAgedAntiviral AgentsFemaleHerpesvirus 3, HumanHumansImmunocompromised HostOxadiazolesAcyclovirAntiviral AgentsASP2151Oxadiazolesamenamevirdisseminated herpes zostervaricella-zoster pneumonia

Identifiers

PMID34776482
PMCPMC9259304
OpenAlexW3213218838

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.