Evidence map›Paper›PMID 34776434›Full record

ReviewJournal of Alzheimer's disease : JAD2022

Connecting Cohorts to Diminish Alzheimer's Disease (CONCORD-AD): A Report of an International Research Collaboration Network.

Valory N Pavlik, Samantha C Burnham, Joseph S Kass, Catherine Helmer, Sebastian Palmqvist, Maria Vassilaki, Jean-François Dartigues, Oskar Hansson, Colin L Masters, Karine Pérès and 8 more

Abstract readReview
In one paragraph

Review in Journal of Alzheimer's disease : JAD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Observational
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Valory N PavlikDepartment of Neurology, Baylor College of Medicine, Houston, TX, USA.
Samantha C BurnhamThe Australian eHealth Research Centre, CSIRO Health and Biosecurity, Melbourne, VIC, Australia.
Joseph S KassDepartment of Neurology, Baylor College of Medicine, Houston, TX, USA.
Catherine HelmerUniversity of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR, Bordeaux, France.
Sebastian PalmqvistClinical Memory Research Unit, Lund University, Lund, Sweden.
Maria VassilakiDepartment of Quantitative Health Sciences, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.
Jean-François DartiguesUniversity of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR, Bordeaux, France.
Oskar HanssonClinical Memory Research Unit, Lund University, Lund, Sweden.
Colin L MastersThe Florey Institute and The University of Melbourne, Parkville, VIC, Australia.
Karine PérèsUniversity of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR, Bordeaux, France.
Ronald C PetersenDepartment of Quantitative Health Sciences, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.
Erik StomrudClinical Memory Research Unit, Lund University, Lund, Sweden.
Lesley ButlerProduct Development Personalised Health Care - Data Science, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Preciosa M ColomaProduct Development Personalised Health Care - Data Science, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Xavier M TeitsmaProduct Development Personalised Health Care - Data Science, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Rachelle DoodyProduct Development Neuroscience, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Mary SanoDepartment of Psychiatry, Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
CONCORD-AD investigators

Funding

SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6M
THE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI PETERSEN, RONALD C · 1999 to 2018
$36.9M
Research Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI KEJAL KANTARCI · 2019 to 2026
$33.5M
Rochester Epidemiology ProjectR01AG034676 · NIA · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A, ST SAUVER, JENNIFER LYNN · 2010 to 2019
$9.5M
Disease pathways in the population determined by amyloid, tau, and neurodegeneration imaging biomarkersR37AG011378 · NIA · MAYO CLINIC ROCHESTER · PI CLIFFORD R. JACK · 2018 to 2026
$6.8M
Validating the New Criteria for Preclinical Alzheimer's diseaseR01AG041851 · NIA · MAYO CLINIC ROCHESTER · PI JACK, CLIFFORD R., KNOPMAN, DAVID S · 2012 to 2021
$6.3M
Development, Validation, and Application of an Imaging based CVD ScaleR01NS097495 · NINDS · MAYO CLINIC ROCHESTER · PI VEMURI, PRASHANTHI · 2016 to 2020
$2.9M
Interdisciplinary Infrastructure for Aging Research: Rochester Epidemiology ProjectR33AG058738 · NIA · MAYO CLINIC ROCHESTER · PI LEBRASSEUR, NATHAN K, OLSON, JANET E · 2020 to 2022
$2.4M
NIA NIH HHS P30 AG062677NIA NIH HHS P50 AG016574NIA NIH HHS R01 AG034676NIA NIH HHS R01 AG041851NIA NIH HHS R33 AG058738NIA NIH HHS R37 AG011378NIA NIH HHS U01 AG006786NINDS NIH HHS R01 NS097495
6 · The paper itself

Abstract

Longitudinal observational cohort studies are being conducted worldwide to understand cognition, biomarkers, and the health of the aging population better. Cross-cohort comparisons and networks of registries in Alzheimer's disease (AD) foster scientific exchange, generate insights, and contribute to the evolving clinical science in AD. A scientific working group was convened with invited investigators from established cohort studies in AD, in order to form a research collaboration network as a resource to address important research questions. The Connecting Cohorts to Diminish Alzheimer's Disease (CONCORD-AD) collaboration network was created to bring together global resources and expertise, to generate insights and improve understanding of the natural history of AD, to inform design of clinical trials in all disease stages, and to plan for optimal patient access to disease-modifying therapies once they become available. The network brings together expertise and data insights from 7 cohorts across Australia, Europe, and North America. Notably, the network includes populations recruited through memory clinics as well as population-based cohorts, representing observations from individuals across the AD spectrum. This report aims to introduce the CONCORD-AD network, providing an overview of the cohorts involved, reporting the common assessments used, and describing the key characteristics of the cohort populations. Cohort study designs and baseline population characteristics are compared, and available cognitive, functional, and neuropsychiatric symptom data, as well as the frequency of biomarker assessments, are summarized. Finally, the challenges and opportunities of cross-cohort studies in AD are discussed.

Indexed as

Alzheimer DiseaseComputer Communication NetworksInternational CooperationAgedBiomarkersCognitionCohort StudiesHumansObservational Studies as TopicBiomarkersAlzheimer’s diseasebiomarkerscognitive functioncohortCONCORD-AD networkdementiaobservational studypopulation characteristics

Identifiers

PMID34776434
PMCPMC8842789

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.