Trial reportNeuroRehabilitation2022
Predicting upper extremity motor improvement following therapy using EEG-based connectivity in chronic stroke.
Trial report in NeuroRehabilitation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Concomitant sensory stimulation during therapy to enhance hand functional recovery post stroke.Trials · 2022Trial
- Evaluation of Cognitive Function in Stroke Patients With Lesions in Different Brain Regions Using P300 Event-Related Potentials Combined With Video EEG.Revista de neurologia · 2025Article
- Associating Functional Neural Connectivity and Specific Aspects of Sensorimotor Control in Chronic Stroke.Sensors (Basel, Switzerland) · 2023Article
- Effect of the Trunk and Upper Limb Passive Stabilization on Hand Movements and Grip Strength Following Various Types of Strokes-An Observational Cohort Study.Brain sciences · 2022Article
- Effect of Sensory Impairment on Hand Functional Improvement with Therapy and Sensory Stimulation.Neurology and neurorehabilitation · 2022Article
- Neuroplasticity after upper-extremity rehabilitation therapy with sensory stimulation in chronic stroke survivors.Brain communications · 2022Article
- Resting-state EEG associated with clinical measures to predict upper limb motor recovery of subacute stroke.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundUncertain prognosis presents a challenge for therapists in determining the most efficient course of rehabilitation treatment for individual patients. Cortical Sensorimotor network connectivity may have prognostic utility for upper extremity motor improvement because the integrity of the communication within the sensorimotor network forms the basis for neuroplasticity and recovery.
objectiveTo investigate if pre-intervention sensorimotor connectivity predicts post-stroke upper extremity motor improvement following therapy.
methodsSecondary analysis of a pilot triple-blind randomized controlled trial. Twelve chronic stroke survivors underwent 2-week task-practice therapy, while receiving vibratory stimulation for the treatment group and no stimulation for the control group. EEG connectivity was obtained pre-intervention. Motor improvement was quantified as change in the Box and Block Test from pre to post-therapy. The association between ipsilesional sensorimotor connectivity and motor improvement was examined using regression, controlling for group. For negative control, contralesional/interhemispheric connectivity and conventional predictors (initial clinical motor score, age, time post-stroke, lesion volume) were examined.
resultsGreater ipsilesional sensorimotor alpha connectivity was associated with greater upper extremity motor improvement following therapy for both groups (p < 0.05). Other factors were not significant.
conclusionEEG connectivity may have a prognostic utility for individual patients' upper extremity motor improvement following therapy in chronic stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.