Evidence map›Paper›PMID 34776274›Full record

ArticleHearing research2022

Coupling between outer hair cell electromotility and prestin sensor charge depends on voltage operating point.

Joseph Santos-Sacchi, Winston J T Tan

Abstract read
In one paragraph

Article in Hearing research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. The Long Outer-Hair-Cell RC Time Constant: A Feature, Not a Bug, of the Mammalian Cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2023
    Review
  4. A Gap-Junction Mutation Reveals That Outer Hair Cell Extracellular Receptor Potentials Drive High-Frequency Cochlear Amplification.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Joseph Santos-SacchiSurgery (Otolaryngology), 333 Cedar Street, New Haven, CT 06510, USA; Neuroscience, 333 Cedar Street, New Haven, CT 06510, USA; Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA. Electronic address: joseph.santos-sacchi@yale.edu.
Winston J T TanSurgery (Otolaryngology), 333 Cedar Street, New Haven, CT 06510, USA.

Funding

Membrane properties of the OHC systemR01DC016318 · NIDCD · YALE UNIVERSITY · PI DHASAKUMAR S NAVARATNAM, JOSEPH R SANTOS-SACCHI · 2017 to 2026
$6.7M
Structural correlates of prestin activity.R01DC008130 · NIDCD · YALE UNIVERSITY · PI NAVARATNAM, DHASAKUMAR S, SANTOS-SACCHI, JOSEPH R · 2007 to 2021
$6.1M
NIDCD NIH HHS R01 DC008130NIDCD NIH HHS R01 DC016318
6 · The paper itself

Abstract

The OHC drives cochlear amplification, and prestin activity is the basis. The frequency response of nonlinear capacitance (NLC), which is a ratiometric measure of prestin's voltage-sensor charge movement (dQ

Indexed as

Hair Cells, Auditory, OuterHair Cells, VestibularCochleaElectric CapacitancePatch-Clamp Techniquescapacitancecochlea amplificationdisplacement currentselectromotilityprestinvoltage-clamp

Identifiers

PMID34776274
PMCPMC9054947

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.