Evidence map›Paper›PMID 34775876›Full record

ArticleCurrent medical research and opinion2022

Missing diagnoses of congenital cytomegalovirus infection in electronic health records for infants with laboratory-confirmed infection.

Alexandra Campione, Tatiana M Lanzieri, Emily Ricotta, Scott D Grosse, Sameer S Kadri, Veronique Nussenblatt, D Rebecca Prevots

Open access · bronzeAbstract read
In one paragraph

Article in Current medical research and opinion, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Anti-cytomegalovirus medications among very low birth weight infants in the United States from 2016 to 2023.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  2. Article
  3. Hearing and neurodevelopmental outcomes among children with congenital cytomegalovirus.International journal of pediatric otorhinolaryngology · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Alexandra CampioneEpidemiology Unit, Division of Intramural Research, National Institutes of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.
Tatiana M LanzieriNational Center for Immunization and Respiratory Diseases, US Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID 0000-0003-2499-4786
Emily RicottaEpidemiology Unit, Division of Intramural Research, National Institutes of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.
Scott D GrosseNational Center on Birth Defects and Developmental Disabilities, US Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID 0000-0003-1078-6855
Sameer S KadriCritical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD, USA.
Veronique NussenblattInfectious Disease, National Institutes of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.
D Rebecca PrevotsEpidemiology Unit, Division of Intramural Research, National Institutes of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-0339-9873
National Institutes of Health · USCenters for Disease Control and Prevention · USNational Institutes of Health Clinical Center · US

Funding

Big Data - Epidemiology of Critical Illness and SepsisZIACL090045 · CLC · CLINICAL CENTER · PI KADRI, SAMEER · 2017 to 2025
$0k
Intramural CDC HHS CC999999
6 · The paper itself

Abstract

Congenital cytomegalovirus (CMV) is a leading cause of non-genetic sensorineural hearing loss and neurodevelopmental disabilities among US children. Studies using administrative healthcare databases have identified infants with congenital CMV using diagnostic codes from the International Classification of Diseases, Ninth and Tenth Revision, Clinical Modification. Using Cerner Health Facts deidentified electronic health records, we assessed the sensitivity of CMV diagnostic codes among infants with laboratory confirmed congenital CMV infection (i.e. a positive CMV laboratory test - polymerase chain reaction, direct fluorescent antibody, or culture from urine, saliva, respiratory secretion or blood samples, or IgM serology - within 21 days of life). During 2010-2017, 668 congenital CMV cases were identified among 7,517,207 infants with encounters within 21 days of life, or 0.89 cases per 10,000 infants. The sensitivity of CMV diagnostic codes assigned within 21 and 90 days of life was 10.3% (95% CI: 8.2-12.9) and 11.1% (95% CI: 8.9-13.7), respectively.

Indexed as

Cytomegalovirus InfectionsHearing Loss, SensorineuralChildElectronic Health RecordsHumansInfantMissed DiagnosisSalivaCongenital cytomegalovirusdiagnostic codeselectronic health recordssensitivity

Identifiers

PMID34775876
PMCPMC9575942
OpenAlexW3211635019

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.