ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2022
White matter damage due to pulsatile versus steady blood pressure differs by vascular territory: A cross-sectional analysis of the UK Biobank cohort study.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 10 citations in OpenAlex.
- Effects of Physical Activity on Brain White Matter Integrity Are Region-, Dose-, and Age-Dependent: Findings From the Population-Based Rhineland Study.Aging cell · 2026Article
- Causal machine learning analysis identifies subpopulations most likely to benefit from healthy lifestyles for cognitive outcomes.General psychiatry · 2026Article
- Pulse Pressure Impairs Cognition via White Matter Disruption.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Complementary MR measures of white matter and their relation to cardiovascular health and cognition.Scientific reports · 2025Article
- Small vessel disease burden and functional brain connectivity in mild cognitive impairment.Cerebral circulation - cognition and behavior · 2024Article
- Cerebral pulsatility in relation with various imaging markers of cerebral small vessel disease: a longitudinal community-based study.Therapeutic advances in neurological disorders · 2024Article
- White matter changes underlie hypertension-related cognitive decline in older adults.NeuroImage. Clinical · 2023Review
- Cell non-autonomous regulation of cerebrovascular aging processes by the somatotropic axis.Frontiers in endocrinology · 2023Review
- Low Heart Rate Is Associated with Cerebral Pulsatility after TIA or Minor Stroke.Annals of neurology · 2022Article
- Retinal nerve fibre layer thickness reflects characteristics of brain grey and white matter.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Small vessel disease is associated with age, mean blood pressure (MAP) and blood pressure pulsatility (PP). We used data from the UK Biobank cohort study to determine the relative importance of MAP versus PP driving white matter injury within individual white matter tracts, particularly in the anterior and posterior vascular territory. The associations between blood pressure and diffusion indices in 27 major tracts were analysed using unadjusted and fully-adjusted general linear models and mixed-effect linear models. Blood pressure and neuroimaging data were available for 37,041 participants (mean age 64+/-7.5 years, 53% female). In unadjusted analyses, MAP and PP were similarly associated with diffusion indices in the anterior circulation. In the posterior circulation, the associations were weaker, particularly for MAP. In fully-adjusted analyses, MAP remained associated with all diffusion indices in the anterior circulation, independently of age. In the posterior circulation, the effect of MAP became protective. PP remained associated with greater mean diffusivity and extracellular free water diffusion in the anterior circulation and all diffusion indices in the posterior circulation. There was a significant interaction between PP and age. This implies discordant mechanisms for chronic white matter injury in different brain regions and potentially in the associated stroke risks.
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