Evidence map›Paper›PMID 34775787›Full record

GuidelineHypertension (Dallas, Tex. : 1979)2022

Hypertension Pharmacological Treatment in Adults: A World Health Organization Guideline Executive Summary.

Akram Al-Makki, Donald DiPette, Paul K Whelton, M Hassan Murad, Reem A Mustafa, Shrish Acharya, Hind Mamoun Beheiry, Beatriz Champagne, Kenneth Connell, Marie Therese Cooney and 14 more

Open access · hybridAbstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Hypertension (Dallas, Tex. : 1979), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 191 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
191citing papers in PubMed, 9 pooled it
45.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

191 citing papers in PubMed, 9 syntheses or guidelines pooled it, 348 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

131 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 20 institutions in 18 countries.

Akram Al-MakkiIndiana University Health Arnett, Lafayette (A.A.-M.).ORCID 0000-0002-4510-8010
Donald DiPetteDepartment of Medicine, University of South Carolina School of Medicine, University of South Carolina, Columbia (D.D.).
Paul K WheltonDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA (P.K.W.).ORCID 0000-0002-2225-383X
M Hassan MuradEvidence-based Practice Center and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN (M.H.M.).
Reem A MustafaDepartment of Internal Medicine, Division of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City (R.A.M.).ORCID 0000-0002-2091-0875
Shrish AcharyaIndiana University Health Arnett, Lafayette (A.A.-M.).
Hind Mamoun BeheiryFaculty of Nursing Sciences, International University of Africa (IUA), Khartoum, Sudan (H.M.B.).
Beatriz ChampagneCoalition for Americas' Health/Coalición América Saludable CLAS, representing civil society organizations in Latin America, Dallas, TX (B.C.).
Kenneth ConnellFaculty of Medical Sciences, The University of the West Indies, Cave Hill Campus, St. Michael, Barbados (K.C.).ORCID 0000-0001-6006-2316
Marie Therese CooneySt. Vincent's University Hospital & University College Dublin, Ireland (M.T.C.).
Nnenna EzeigweFederal Ministry of Health, Abuja, Nigeria (N.E.).
Thomas Andrew GazianoHarvard Medical School, Boston, MA (T.A.G.).ORCID 0000-0002-5985-345X
Agaba GidioMulago National Referral Hospital, Kampala, Uganda (A.G.).
Patricio Lopez-JaramilloMasira Research Institute, Medical School, Universidad de Santander, Bucaramanga, Colombia (P.L.-J.).
Unab I KhanDepartment of Family Medicine, The Aga Khan University, Pakistan (U.I.K.).
Vindya KumarapeliDirectorate of Non-Communicable Diseases, Ministry of Health, Colombo, Sri Lanka (V.K.).ORCID 0000-0002-2852-7790
Andrew E MoranGlobal Hypertension Control, Resolve to Save Lives, an initiative of Vital Strategies, NY (A.E.M.).
Margaret Mswema SilwimbaUniversity Teaching Hospital (Adult), Lusaka, Zambia and Faculty of Pharmacy, Lusaka Apex Medical University (M.M.S.).
Brian RaynerDivision of Nephrology and Hypertension, Groote Schuur Hospital and University of Cape Town, South Africa (B.R.).ORCID 0000-0002-0167-9591
Apichard SukonthasanDepartment of Medicine, Bangkok Hospital Chiang Mai, Mueang Chiang Mai, Thailand (A.S.).
Jing YuHypertension Center, Department of Cardiology, Lanzhou University Second Hospital, China (J.Y.).
Nizal SaraffzadeganIsfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Iran (N.S.).
K Srinath ReddyPublic Health Foundation of India, New Delhi (K.S.R.).
Taskeen KhanDepartment of Non-Communicable Diseases, World Health Organization, Geneva, Switzerland (T.K.).
Indiana University Health · USAga Khan University · PKBangkok Hospital · THBrigham and Women's Hospital · USColumbia University Irving Medical Center · USFederal Ministry of Health · NGGroote Schuur Hospital · ZAInfectious Diseases Society of America · USInternational University of Africa · SDIsfahan University of Medical Sciences · IRLanzhou University Second Hospital · CNLusaka Apex Medical University · ZMMayo Clinic in Arizona · USMinistry of Health, Nutrition and Indigenous Medicine · LKMulago Hospital · UGPublic Health Foundation of India · INSt. Vincent's University Hospital · IETulane University · USUniversidad De Santander · COUniversity of Kansas Medical Center · US

Funding

World Health Organization 001
6 · The paper itself

Abstract

Hypertension is a major cause of cardiovascular disease and deaths worldwide especially in low- and middle-income countries. Despite the availability of safe, well-tolerated, and cost-effective blood pressure (BP)-lowering therapies, <14% of adults with hypertension have BP controlled to a systolic/diastolic BP <140/90 mm Hg. We report new hypertension treatment guidelines, developed in accordance with the World Health Organization Handbook for Guideline Development. Overviews of reviews of the evidence were conducted and summary tables were developed according to the Grading of Recommendations, Assessment, Development, and Evaluations approach. In these guidelines, the World Health Organization provides the most current and relevant evidence-based guidance for the pharmacological treatment of nonpregnant adults with hypertension. The recommendations pertain to adults with an accurate diagnosis of hypertension who have already received lifestyle modification counseling. The guidelines recommend BP threshold to initiate pharmacological therapy, BP treatment targets, intervals for follow-up visits, and best use of health care workers in the management of hypertension. The guidelines provide guidance for choice of monotherapy or dual therapy, treatment with single pill combination medications, and use of treatment algorithms for hypertension management. Strength of the recommendations was guided by the quality of the underlying evidence; the tradeoffs between desirable and undesirable effects; patient's values, resource considerations and cost-effectiveness; health equity; acceptability, and feasibility consideration of different treatment options. The goal of the guideline is to facilitate standard approaches to pharmacological treatment and management of hypertension which, if widely implemented, will increase the hypertension control rate world-wide.

Indexed as

Antihypertensive AgentsBlood PressureHumansHypertensionWorld Health OrganizationAntihypertensive Agentsblood pressurecardiovascular diseasehypertensionpharmacotherapy

Identifiers

PMID34775787
PMCPMC8654104
OpenAlexW3213301568

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.