ArticleBrain and behavior2021
Clinical epidemiological characteristics of nitrous oxide abusers: A single-center experience in a hospital in China.
Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Review
- Recreational Nitrous Oxide Use and Associated Neuropsychiatric Presentations in Patients Attending the Emergency Department.Epidemiologia (Basel, Switzerland) · 2025Article
- Rare but relevant: Nitrous oxide and peripheral neurotoxicity, what do we know?Addiction (Abingdon, England) · 2025Review
- Severe subacute combined degeneration of the spinal cord resulting from nitrous oxide (N2O) abuse: a case series.Neurological research and practice · 2025Article
- Nitrous Oxide-Induced Vitamin B12 Deficiency and Myelopathy in Whippets Abusers: A Report of Two Cases.Cureus · 2024Article
- Nitrous oxide abuse in a 21-year-old female: a case report and review of literature.Frontiers in neurology · 2024Review
- Nitrous Oxide Abuse: Clinical Outcomes, Pharmacology, Pharmacokinetics, Toxicity and Impact on Metabolism.Toxics · 2023Review
- Nitrous Oxide Inhalant Abuse: Preliminary Results from a Cross-Sectional Study on Knowledge, Attitudes, and Practices of Italian Physicians (2023).Medicina (Kaunas, Lithuania) · 2023Article
- Article
- Vitamin B12 Status in Recreational Users of Nitrous Oxide: A Systematic Review Focusing on the Prevalence of Laboratory Abnormalities.Antioxidants (Basel, Switzerland) · 2023Review
- Severe length-dependent peripheral polyneuropathy in a patient with subacute combined spinal cord degeneration secondary to recreational nitrous oxide abuse: A case report and literature review.Clinical case reports · 2023Article
- Case report: Recreational nitrous oxide abuse triggered peripheral neuropathy possibly through the immune-mediated pathogenesis.Frontiers in neurology · 2022Article
- Clinical epidemiological characteristics of nitrous oxide abusers: A single-center experience in a hospital in China.Brain and behavior · 2021Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study investigated the clinical epidemiological characteristics of nitrous oxide (N
methodsThe characteristics of patients abusing N
resultsA total of 61 patients (average age: 21.7 ± 3.2 years; 42 male and 19 female) were enrolled; 60.7% of the patients had an education level of high school or lower, and most (59.0%) had no stable occupation. The mean exposure time was 8.5 ± 7.7 months (range: 1-36 months). Only 52.5% of the abusers reported the physician of the relevant exposure history at the first time of visiting the doctor. The main clinical type was mixed (49.2%). The most common clinical manifestation was distal limb numbness (80.3%). The most frequent outcome was peripheral neuropathy (59%) and subacute combined degeneration (36%). Serum homocysteine level was elevated in 67.5% (27/40) of the patients, while 44.4% (20/45) showed reduced vitamin B12. Note that 61% (22/36) showed abnormal signals in the posterior or lateral funiculus of the spinal cord, and 97% (31/32) of the patients showed peripheral nerve damage by electromyography. In all cases, symptoms were alleviated after halting N
conclusionsN
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