ArticlePediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2022
Asthma as a risk factor for hospitalization in children with COVID-19: A nested case-control study.
Article in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Comparative Analysis of Outcomes of Influenza and COVID-19 Admissions Among Children With Asthma: A Nationwide Retrospective Cohort Study Using the US National Readmissions Database.JMIR medical informatics · 2025Article
- Observational Study: Lung Function and Symptom Control in Youth With Asthma up to 34 Months After COVID-19.Pediatric pulmonology · 2025Observational
- All-cause hospital admissions and incidence of asthma in children in Kazakhstan: a population-based retrospective cohort study.Scientific reports · 2025Article
- Preschool Asthma Children: Navigating COVID-19's Impact on Treatment Adherence.Turkish archives of pediatrics · 2025Article
- COVID-19 frequency and clinical course in children with asthma.World journal of virology · 2023Article
- Odds of COVID-19-associated asthma exacerbations in children higher during Omicron wave.Pediatric pulmonology · 2023Article
- The Impact of SARS-CoV-2 Infection on Symptom Control and Lung Function in Children with Asthma.Annals of the American Thoracic Society · 2023Article
- Characteristics and Risk Factors Associated with SARS-CoV-2 Pneumonias in Hospitalized Pediatric Patients: A Pilot Study.Children (Basel, Switzerland) · 2023Article
- Article
- Impact of SARS-CoV-2 Infection in Children with Asthma and Impact of COVID-19 Vaccination: Current Evidence and Review of the Literature.Microorganisms · 2023Review
- Impact of the COVID-19 on asthma control among children: A systematic review.Journal of public health research · 2023Review
- Multilevel Analysis of Racial and Ethnic Disparities in COVID-19 Hospitalization among Children with Allergies.Annals of the American Thoracic Society · 2023Article
- Recent developments in the immunopathology of COVID-19.Allergy · 2023Review
- Hospitalizations and deaths of children and adolescents with Severe Acute Respiratory Infection due to COVID-19 during the epidemiological year of 2020.Revista do Instituto de Medicina Tropical de Sao Paulo · 2023Article
- A population-based serological study of post-COVID syndrome prevalence and risk factors in children and adolescents.Nature communications · 2022Article
- Article
- Asthma as a risk factor for hospitalization in children with COVID-19: A nested case-control study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Article
- Risk factors for admission to the pediatric critical care unit among children hospitalized with COVID-19 in France.Frontiers in pediatrics · 2022Article
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Abstract
backgroundMost pediatric studies of asthma and COVID-19 to date have been ecological, which offer limited insight. We evaluated the association between asthma and COVID-19 at an individual level.
methodsUsing data from prospective clinical registries, we conducted a nested case-control study comparing three groups: children with COVID-19 and underlying asthma ("A+C" cases); children with COVID-19 without underlying disease ("C+" controls); and children with asthma without COVID-19 ("A+" controls).
resultsThe cohort included 142 A+C cases, 1110 C+ controls, and 140 A+ controls. A+C cases were more likely than C+ controls to present with dyspnea and wheezing, to receive pharmacologic treatment including systemic steroids (all p < .01), and to be hospitalized (4.9% vs. 1.7%, p = .01). In the adjusted analysis, A+C cases were nearly 4 times more likely to be hospitalized than C+ controls (adjusted OR = 3.95 [95%CI = 1.4-10.9]); however, length of stay and respiratory support level did not differ between groups. Among A+C cases, 8.5% presented with an asthma exacerbation and another 6.3% developed acute exacerbation symptoms shortly after testing positive for SARS-CoV-2. Compared to historic A+ controls, A+C cases had less severe asthma, were less likely to be on controller medications, and had better asthma symptom control (all p < .01).
conclusionsIn our cohort, asthma was a risk factor for hospitalization in children with COVID-19, but not for worse COVID-19 outcomes. SARS-CoV-2 does not seem to be a strong trigger for pediatric asthma exacerbations. Asthma severity was not associated with higher risk of COVID-19.
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