Evidence map›Paper›PMID 34775120›Full record

ArticleBehaviour research and therapy2022

Levels of depressed mood and low interest for two years after response to cognitive therapy for recurrent depression.

Jeffrey R Vittengl, Lee Anna Clark, Michael E Thase, Robin B Jarrett

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behaviour research and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Evaluating a Comprehensive Model of Euthymia.Psychotherapy and psychosomatics · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Jeffrey R VittenglDepartment of Psychology, Truman State University, Kirksville, MO, USA. Electronic address: vittengl@truman.edu.
Lee Anna ClarkDepartment of Psychology, University of Notre Dame, Notre Dame, IN, USA.
Michael E ThaseDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Robin B JarrettDepartment of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: robin.jarrett@utsouthwestern.edu.
Southwestern Medical Center · USTruman State University · USUniversity of Notre Dame · USUniversity of Pennsylvania · US

Funding

PROPHYLACTIC COGNITIVE THERAPY FOR DEPRESSIONR01MH058397 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI JARRETT, ROBIN B · 2000 to 2011
$4.1M
PROPHYLACTIC COGNITIVE THERAPY FOR DEPRESSIONR01MH058356 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI THASE, MICHAEL E · 2000 to 2010
$3.5M
Are Cognitive Therapy's Antidepressant Effects Durable?R01MH069619 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI JARRETT, ROBIN B · 2004 to 2009
$1.7M
Are Cognitive Therapy's Antidepressant Effects Durable?R01MH069618 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FRIEDMAN, EDWARD S. · 2004 to 2008
$1.5M
Cognitive Therapy for High Risk &Refractory DepressionK24MH001571 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI JARRETT, ROBIN B · 2005 to 2009
$625k
COGNITIVE THERAPY FOR HIGH RISK &REFRACTORY DEPRESSIONK02MH001571 · NIMH · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI JARRETT, ROBIN B · 1999 to 2003
$458k
NIMH NIH HHS K02 MH001571NIMH NIH HHS K24 MH001571NIMH NIH HHS R01 MH058356NIMH NIH HHS R01 MH058397NIMH NIH HHS R01 MH069618NIMH NIH HHS R01 MH069619
6 · The paper itself

Abstract

backgroundMajor depressive disorder (MDD) involves depressed mood (high negative affect, predominantly) and low interest/pleasure (low positive affect). In past research, negative affect has improved more than positive affect during acute-phase antidepressant medication or cognitive therapy (CT). We extended this literature by differentiating depressed mood and two dimensions of low interest (general and sexual), assessing persistence of symptom differences after acute-phase CT response, and testing whether continuation treatment acted differently on depressed mood versus low interest.

methodsWe analyzed data from two randomized controlled trials. Patients with recurrent MDD first received acute-phase CT. Then, responders were randomized to 8-month continuation treatments and assessed for 16-24 additional months.

resultsDepressed mood and low general interest improved more than low sexual interest during acute-phase CT. Among responders, these symptom differences persisted for at least 2 years and were not changed by continuation CT or antidepressant medication. LIMITATIONS: Generalization of findings to other patient populations and treatments is uncertain. Depressed mood and low interest scales were constructed from standard symptom measures and overlapped empirically.

conclusionsLess improvement during CT, and persistent low sexual interest despite continuation treatment, highlights the need for MDD treatments more effectively targeting this positive affective symptom.

Indexed as

Cognitive Behavioral TherapyMajor Depressive DisorderAntidepressive AgentsDepressionHumansRandomized Controlled Trials as TopicRecurrenceAntidepressive AgentsAnhedoniaCognitive therapyContinuation treatmentDepressionNegative affectPositive affect

Identifiers

PMID34775120
PMCPMC8712398
OpenAlexW3213358571

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.