ArticleThe American journal of pathology2022
Collagen XII Regulates Corneal Stromal Structure by Modulating Transforming Growth Factor-β Activity.
Article in The American journal of pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Impact of the loss of tenascin X on tissue architecture and wound healing of the murine corneal stroma.The ocular surface · 2026Article
- Latent-Transforming growth factor - β Binding protein 1 (LTBP1) in corneal stroma.Matrix biology plus · 2025Article
- Review
- Mechanical Strain of Corneal Epithelium Influences the Expression of Genes Implicated in Keratoconus.Investigative ophthalmology & visual science · 2025Article
- Dysfunctional latent transforming growth factor β activation after corneal injury in a classical Ehlers-Danlos model.Matrix biology : journal of the International Society for Matrix Biology · 2024Article
- Collagen type XII is undetectable in keratoconus Bowman's layer.The British journal of ophthalmology · 2024Article
- The coordinated activities of collagen VI and XII in maintenance of tissue structure, function and repair: evidence for a physical interaction.Frontiers in molecular biosciences · 2024Article
- Keratocyte-Derived Myofibroblasts: Functional Differences With Their Fibroblast Precursors.Investigative ophthalmology & visual science · 2023Article
- Collagen XII regulates stromal wound closure.Experimental eye research · 2023Article
- Genipin increases extracellular matrix synthesis preventing corneal perforation.The ocular surface · 2023Article
- Collagen XII mediated cellular and extracellular mechanisms in development, regeneration, and disease.Frontiers in cell and developmental biology · 2023Review
- Multiple Optical Elastography Techniques Reveal the Regulation of Corneal Stiffness by Collagen XII.Investigative ophthalmology & visual science · 2022Article
- Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis.Nature communications · 2022Article
- Type XX Collagen Is Elevated in Circulation of Patients with Solid Tumors.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
Abstract
Collagen XII is a regulator of corneal stroma structure and function. The current study examined the role of collagen XII in regulating corneal stromal transforming growth factor (TGF)-β activation and latency. Specifically, with the use of conventional collagen XII null mouse model, the role of collagen XII in the regulation of TGF-β latency and activity in vivo was investigated. Functional quantification of latent TGF-β in stromal matrix was performed by using transformed mink lung reporter cells that produce luciferase as a function of active TGF-β. Col12a1 knockdown with shRNA was used to test the role of collagen XII in TGF-β activation. Col12a1
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.