Evidence map›Paper›PMID 34774600›Full record

ArticleInternational journal of biological macromolecules2021

Structural and functional significance of the amino acid differences Val

Alexander I Denesyuk, Eugene A Permyakov, Mark S Johnson, Sergei E Permyakov, Konstantin Denessiouk, Vladimir N Uversky

Open access · greenAbstract read
In one paragraph

Article in International journal of biological macromolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Alexander I DenesyukInstitute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", Pushchino Moscow Region 142290, Russia; Structural Bioinformatics Laboratory, Biochemistry, InFLAMES Research Flagship Center Faculty of Science and Engineering, Åbo Akademi University, Turku 20520, Finland. Electronic address: adenesyu@abo.fi.
Eugene A PermyakovInstitute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", Pushchino Moscow Region 142290, Russia.
Mark S JohnsonStructural Bioinformatics Laboratory, Biochemistry, InFLAMES Research Flagship Center Faculty of Science and Engineering, Åbo Akademi University, Turku 20520, Finland.
Sergei E PermyakovInstitute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", Pushchino Moscow Region 142290, Russia.
Konstantin DenessioukStructural Bioinformatics Laboratory, Biochemistry, InFLAMES Research Flagship Center Faculty of Science and Engineering, Åbo Akademi University, Turku 20520, Finland.
Vladimir N UverskyInstitute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", Pushchino Moscow Region 142290, Russia; Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA. Electronic address: vuversky@usf.edu.
Åbo Akademi University · FIPushchino Scientific Center for Biological Research

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Three dimensional structures of (chymo)trypsin-like proteinase (3CL

Indexed as

Coronavirus 3C ProteasesMutation, MissenseSARS-CoV-2Severe acute respiratory syndrome-related coronavirusAmino Acid SubstitutionHumansProtein DomainsSpecies SpecificityStructure-Activity Relationship3C-like protease, SARS coronavirus3C-like proteinase, SARS-CoV-2Coronavirus 3C ProteasesAutolysisCatalytic tetrad(Chymo)trypsin-like proteinasesCOVID-19Interdomain loopSARS-CoV-2Structural catalytic core

Identifiers

PMID34774600
PMCPMC8580570
OpenAlexW3214557393

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.