Evidence map›Paper›PMID 34774514›Full record

ReviewThe American journal of pathology2022

Slide Over: Advances in Slide-Free Optical Microscopy as Drivers of Diagnostic Pathology.

Yehe Liu, Richard M Levenson, Michael W Jenkins

Open access · bronzeAbstract readReview
In one paragraph

Review in The American journal of pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Detecting drug-induced nephrotoxicity using simultaneous label-free autofluorescence multiharmonic microscopy.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Current Landscape of Advanced Imaging Tools for Pathology Diagnostics.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Observational
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Yehe LiuDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.
Richard M LevensonDepartment of Pathology and Laboratory Medicine, University of California-Davis, Sacramento, California. Electronic address: levenson@ucdavis.edu.
Michael W JenkinsDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio. Electronic address: mwj5@case.edu.
Case Western Reserve University · USUniversity of California System · US

Funding

3D Microscopy with Ultraviolet Surface Excitation (3D-MUSE)R01EB028635 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI LEVENSON, RICHARD M., WILSON, DAVID LYNN · 2019 to 2023
$2.7M
Breast core-needle diagnostics in LMICs via millifluidics and direct-to-digital imaging: development and validation in GhanaU01CA269191 · NCI · UNIVERSITY OF WASHINGTON · PI RICHARD M. LEVENSON, Eric J Seibel · 2023 to 2026
$2.4M
Imaging and informatics techniques to spatially map tumor-associated collagen: novel cancer diagnostic tools (2 of 2)R33CA202881 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEVENSON, RICHARD M. · 2017 to 2019
$1.3M
IMAT-ITCR Collaboration: Combining FIBI and topological data analysis: Synergistic approaches for tumor structural microenvironment explorationR33CA278544 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ICZKOWSKI, KENNETH A · 2023 to 2025
$988k
NCI NIH HHS R33 CA202881NCI NIH HHS R33 CA278544NCI NIH HHS U01 CA269191NIBIB NIH HHS R01 EB028635
6 · The paper itself

Abstract

Conventional analysis using clinical histopathology is based on bright-field microscopy of thinly sliced tissue specimens. Although bright-field microscopy is a simple and robust method of examining microscope slides, the preparation of the slides needed is a lengthy and labor-intensive process. Slide-free histopathology, however, uses direct imaging of intact, minimally processed tissue samples using advanced optical-imaging systems, bypassing the extended workflow now required for the preparation of tissue sections. This article explains the technical basis of slide-free microscopy, reviews common slide-free optical microscopy techniques, and discusses the opportunities and challenges involved in clinical implementation.

Indexed as

Image Processing, Computer-AssistedMicroscopyPathology, ClinicalHumans

Identifiers

PMID34774514
PMCPMC8883436
OpenAlexW3213259674

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.