Evidence map›Paper›PMID 34774500›Full record

ArticleBrain research2022

Peripherally administered cannabinoid receptor 2 (CB

Jenny L Wilkerson, Lauren B Alberti, Ganesh A Thakur, Alexandros Makriyannis, Erin D Milligan

Open access · greenAbstract read
In one paragraph

Article in Brain research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Review
  3. Cannabinoid CBBritish journal of pharmacology · 2025
    Review
  4. Article
  5. Review
  6. Mitragynine and morphine produce dose-dependent bimodal action on food but not water intake in rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2024
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. The role of protein kinases in diabetic neuropathic pain: an update review.Journal of diabetes and metabolic disorders · 2023
    Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jenny L WilkersonDepartment of Neurosciences, Health Sciences Center, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA.
Lauren B AlbertiDepartment of Neurosciences, Health Sciences Center, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA.
Ganesh A ThakurCenter for Drug Discovery, Northeastern University, Boston, MA 02115, USA.
Alexandros MakriyannisCenter for Drug Discovery, Northeastern University, Boston, MA 02115, USA.
Erin D MilliganDepartment of Neurosciences, Health Sciences Center, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA. Electronic address: Emilligan@salud.unm.edu.
University of New Mexico · USNortheastern University · US

Funding

Understanding neurophysiological deficits in response inhibition in children with FASDP50AA022534 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Carlos Fernando Valenzuela · 2014 to 2026
$21.5M
Spinal Neuroimmune Mechanisms Underlying IL-10 Gene Therapy for Pain ControlR01DA018156 · NIDA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI MILLIGAN, ERIN DAMITA · 2004 to 2014
$3.3M
Prenatal Alcohol Exposure Potentiates Pain via Lifelong Spinal-immune ChangesR01AA025967 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI MILLIGAN, ERIN DAMITA · 2017 to 2021
$1.5M
Chronic neuropathic pain, glial-immune responses and fetal alcohol exposureR21AA023051 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI MILLIGAN, ERIN DAMITA, NORENBERG, JEFFREY PAUL · 2015 to 2016
$400k
NIAAA NIH HHS P50 AA022534NIAAA NIH HHS R01 AA025967NIAAA NIH HHS R21 AA023051NIDA NIH HHS R01 DA018156
6 · The paper itself

Abstract

The transient receptor potential (TRP) superfamily of cation channels, of which the TRP vanilloid type 1 (TRPV1) receptor plays a critical role in inflammatory and neuropathic pain, is expressed on nociceptors and spinal cord dorsal horn neurons. TRPV1 is also expressed on spinal astrocytes and dorsal root ganglia (DRG) satellite cells. Agonists of the cannabinoid type 2 receptor (CB

Indexed as

AnimalsCannabinoid Receptor AgonistsChemokine CCL2ChromonesGanglia, SpinalGlial Fibrillary Acidic ProteinHyperalgesiaMiceMice, KnockoutReceptor, Cannabinoid, CB2Spinal CordTRPV Cation Channels3-(1,1-dimethyl-heptyl)-1-hydroxy-9-methoxy-benzo(c)chromen-6-oneCannabinoid Receptor AgonistsChemokine CCL2ChromonesGlial Fibrillary Acidic Proteinglial fibrillary astrocytic protein, mouseReceptor, Cannabinoid, CB2TRPV1 protein, mouseTRPV Cation ChannelsDRGMousePainParaffin immunohistochemistrySpectral analysis

Identifiers

PMID34774500
PMCPMC10763621
OpenAlexW3212260319

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.