Evidence map›Paper›PMID 34774131›Full record

ArticleMolecular cell2021

Balancing of mitochondrial translation through METTL8-mediated m

Eva Schöller, James Marks, Virginie Marchand, Astrid Bruckmann, Christopher A Powell, Markus Reichold, Christian Daniel Mutti, Katja Dettmer, Regina Feederle, Stefan Hüttelmaier and 6 more

Open access · greenAbstract read
In one paragraph

Article in Molecular cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.

  1. Pooled it
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  14. Interpreting ribosome dynamics during mRNA translation.The Journal of biological chemistry · 2025
    Review
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  16. Article
  17. Article
  18. Review
  19. Structural basis of tRNA recognition by the mNature structural & molecular biology · 2024
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 4 countries.

Eva SchöllerRegensburg Center for Biochemistry (RCB), Laboratory for RNA Biology, University of Regensburg, 93053 Regensburg, Germany.
James MarksRNA Molecular Biology Group, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Virginie MarchandUniversité de Lorraine, CNRS, INSERM, UMS2008/US40 IBSLor, EpiRNA-Seq Core facility, 54000 Nancy, France.
Astrid BruckmannRegensburg Center for Biochemistry (RCB), Laboratory for RNA Biology, University of Regensburg, 93053 Regensburg, Germany.
Christopher A PowellMedical Research Council Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK.
Markus ReicholdMedical Cell Biology, Institute of Physiology, University of Regensburg, 93053 Regensburg, Germany.
Christian Daniel MuttiMedical Research Council Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK.
Katja DettmerInstitute of Functional Genomics, University of Regensburg, 93053 Regensburg, Germany.
Regina FeederleMonoclonal Antibody Core Facility, Institute for Diabetes and Obesity, Helmholtz-Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Stefan HüttelmaierInstitute of Molecular Medicine, Section for Molecular Cell Biology, Faculty of Medicine, Martin-Luther-University Halle-Wittenberg, 06120 Halle, Germany.
Mark HelmInstitute of Pharmacy and Biochemistry, Johannes Gutenberg-University, Staudingerweg 5, 55128 Mainz, Germany.
Peter OefnerInstitute of Functional Genomics, University of Regensburg, 93053 Regensburg, Germany.
Michal MinczukMedical Research Council Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK.
Yuri MotorinUniversité de Lorraine, CNRS, INSERM, UMS2008/US40 IBSLor, EpiRNA-Seq Core facility, 54000 Nancy, France; Université de Lorraine, CNRS, UMR7365 IMoPA, 54000 Nancy, France.
Markus HafnerRNA Molecular Biology Group, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Gunter MeisterRegensburg Center for Biochemistry (RCB), Laboratory for RNA Biology, University of Regensburg, 93053 Regensburg, Germany. Electronic address: gunter.meister@ur.de.
University of Regensburg · DEUniversity of Cambridge · GBCentre National de la Recherche Scientifique · FRNational Institutes of Health · USHelmholtz Zentrum München · DEJohannes Gutenberg University Mainz · DEMartin Luther University Halle-Wittenberg · DE

Funding

Intramural NIH HHS Z99 AR999999Medical Research Council MC_UU_00015/4Medical Research Council MC_UU_00015/7
6 · The paper itself

Abstract

Mitochondria contain a specific translation machinery for the synthesis of mitochondria-encoded respiratory chain components. Mitochondrial tRNAs (mt-tRNAs) are also generated from the mitochondrial DNA and, similar to their cytoplasmic counterparts, are post-transcriptionally modified. Here, we find that the RNA methyltransferase METTL8 is a mitochondrial protein that facilitates 3-methyl-cytidine (m

Indexed as

AnimalsAnticodonCell ProliferationCodonCytoplasmDNA, MitochondrialElectron TransportGreen Fluorescent ProteinsHEK293 CellsHumansMethyltransferasesMiceMitochondriaMitochondrial MembranesMitochondrial ProteinsOxygen ConsumptionAnticodonCodonDNA, MitochondrialGreen Fluorescent Proteinsm(5)C rRNA methyltransferaseMethyltransferasesMETTL8 protein, humanMettl8 protein, mouseMitochondrial ProteinsRNA, MitochondrialRNA, Transferm(3)CMETTL8mt-tRNARNA modificationtranslation

Identifiers

PMID34774131
PMCPMC11214777
OpenAlexW3211977161

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.