Evidence map›Paper›PMID 34774049›Full record

ArticleMolecular cancer2021

DREAM: a database of experimentally supported protein-coding RNAs and drug associations in human cancer.

Shupeng Li, Lulu Li, Xiangqi Meng, Penggang Sun, Yi Liu, Yuntang Song, Sijia Zhang, Chuanlu Jiang, Jinquan Cai, Zheng Zhao

Open access · goldAbstract readLetter
In one paragraph

Article in Molecular cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

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  3. [Research Progress in Imaging Investigation of TERT Promoter Mutations in Gliomas].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024
    Review
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  6. BCEDB: a linear B-cell epitopes database for SARS-CoV-2.Database : the journal of biological databases and curation · 2023
    Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Shupeng Li *Department of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences, Harbin, 150086, China.
Lulu Li *Department of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences, Harbin, 150086, China.
Xiangqi MengDepartment of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences, Harbin, 150086, China.
Penggang SunDepartment of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences, Harbin, 150086, China.
Yi LiuDepartment of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences, Harbin, 150086, China.
Yuntang SongDepartment of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences, Harbin, 150086, China.
Sijia ZhangDepartment of Educational Administration, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
Chuanlu JiangDepartment of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences, Harbin, 150086, China. jcl6688@163.com.ORCID 0000-0003-0457-1145
Jinquan CaiDepartment of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences, Harbin, 150086, China. caijinquan666777@126.com.
Zheng ZhaoBeijing Neurosurgical Institute, Capital Medical University, Beijing, 100070, China. zhaozheng0503@ccmu.edu.com.
Harbin Medical University · CNCapital Medical University · CN

Funding

excellent young talents project of central government supporting local university reform and development fund 0202-300011190006heilongjiang provincial postdoctoral science foundation LBH-Z19029karolinska institutet research foundation grants 2020-2021 FS-2020:0007National College Students Innovation and Entrepreneurship Training Program 202110226013national natural science foundation of china 81874204national natural science foundation of china 81972817national natural science foundation of china 82002647national natural science foundation of china 82073298postdoctoral research foundation of china 2019M660074postdoctoral research foundation of china 2020T130157the research project of the health and family planning commission of heilongjiang province 2019-102
6 · The paper itself

Abstract

The Drug Response Gene Expression Associated Map, also referred as "DREAM" ( http://bio-big-data.cn:8080/DREAM ), is a manually curated database of experimentally supported protein-coding RNAs and drugs associations in human cancers. The current version of the DREAM documents 3048 entries about scientific literatures supported drug sensitivity or drug intervention related protein-coding RNAs from PubMed database and 195 high-throughput microarray data about drug sensitivity or drug intervention related protein-coding RNAs data from GEO database. Each entry in DREAM database contains detailed information on protein-coding RNA, drug, cancer, and other information including title, PubMed ID, journal, publish time. The DREAM database also provides some data visualization and online analysis services such as volcano plot, GO/KEGG enrichment function analysis, and novel drug discovery analysis. We hope the DREAM database should serve as a valuable resource for clinical practice and basic research, which could help researchers better understand the effects of protein-coding RNAs on drug response in human cancers.

Indexed as

Databases, GeneticDrug DiscoveryOpen Reading FramesGene Expression RegulationHumansRNA, MessengerRNA, MessengerDatabaseData visualizationDrugsHuman cancers

Identifiers

PMID34774049
PMCPMC8590212
OpenAlexW3211727389

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.