SynthesisBMC public health2021
Risk and protective factors of drug abuse among adolescents: a systematic review.
Synthesis in BMC public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06821035 (Teaching Youth & Families Self-Regulation Skills to Disrupt the Impact of Adverse Childhood Experiences), which is not on this map. Cited by 168 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Teaching Youth & Families Self-Regulation Skills to Disrupt the Impact of Adverse Childhood Experiences: Preventing Substance Use in Adversity- Impacted Youth
Who cites it
168 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Definitions of community-level approaches to address substance-related harms and lessons learned: A systematic overview of reviews.American journal of community psychology · 2026Pooled it
- Substance Use Disorders in Adolescents: A Qualitative Systematic Review.Journal of advanced nursing · 2026Pooled it
- A systematic review of reviews on comprehensive community initiatives to prevent or reduce alcohol and other drug harms.Addiction (Abingdon, England) · 2026Pooled it
- A systematic review and meta-analysis of factors associated with adolescent substance use in Africa, 2000 to 2020.Addiction (Abingdon, England) · 2025Pooled it
- Racism-related experiences and substance use: A systematic and meta-analytic review.Social science & medicine (1982) · 2024Pooled it
- Factors Influencing the Use of Tobacco Among Youth in Low-Income, Lower-Middle-Income, and Upper-Middle-Income Countries: A Systematic Review.Journal of research in health sciences · 2024Pooled it
- Substance use among young people in sub-Saharan Africa: a systematic review and meta-analysis.Frontiers in psychiatry · 2024Pooled it
- Subcellular Effectors of Cocaine Cardiotoxicity: All Roads Lead to Mitochondria-A Systematic Review of the Literature.International journal of molecular sciences · 2023Pooled it
- Aerobic exercise and NBS superfood supplementation modulate iron-related biomarkers in methadone treated men in randomized double blind controlled trial.Scientific reports · 2025Trial
- Disease-Tailored Brief Intervention for Alcohol Use Among Youths With Chronic Medical Conditions: A Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2024Trial
- Association between latent classes of tobacco, e-cigarette, alcohol, and illicit drug use patterns and depression among Thai adolescents.Addictive behaviors reports · 2026Article
- A narrative review of school-based preventive interventions on mental disorders and addictions.Discover mental health · 2026Review
- The Role of Anterior Insular Parvalbumin GABAergic Interneurons in Impulsivity-Related and Alcohol-Seeking Behaviors.CNS neuroscience & therapeutics · 2026Article
- Association between substance use disorder and risky behavior among students in Indonesia: a cross-sectional study.Korean journal of family medicine · 2026Article
- Place-based risk: Examining relationships between adolescent perceptions of community risk factors and adolescent substance use across geographic contexts.American journal of community psychology · 2026Article
- Socio-Demographic Factors Associated with Alcohol and Tobacco Use Among Virally Suppressed People Living with HIV in the Eastern Cape, South Africa.Tropical medicine and infectious disease · 2026Article
- Integrated Education Models for Addressing Substance Use Among Schoolchildren: A Scoping Review of School-Based Educational Interventions.International journal of environmental research and public health · 2026Article
- Substance Use Disorders in the Orthodox Jewish Community: A Scoping Review.Journal of religion and health · 2026Article
- Latent classes of substance use precursors predict positive alcohol and cannabis expectancies one year later in Black and Latino early adolescents in the ABCD study.Addictive behaviors · 2026Article
- Establishment of a Novel Approach for Drug Abuse Monitoring and Its Application in Medical Institutions.Medical science monitor : international medical journal of experimental and clinical research · 2026Observational
108 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDrug abuse is detrimental, and excessive drug usage is a worldwide problem. Drug usage typically begins during adolescence. Factors for drug abuse include a variety of protective and risk factors. Hence, this systematic review aimed to determine the risk and protective factors of drug abuse among adolescents worldwide.
methodsPreferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was adopted for the review which utilized three main journal databases, namely PubMed, EBSCOhost, and Web of Science. Tobacco addiction and alcohol abuse were excluded in this review. Retrieved citations were screened, and the data were extracted based on strict inclusion and exclusion criteria. Inclusion criteria include the article being full text, published from the year 2016 until 2020 and provided via open access resource or subscribed to by the institution. Quality assessment was done using Mixed Methods Appraisal Tools (MMAT) version 2018 to assess the methodological quality of the included studies. Given the heterogeneity of the included studies, a descriptive synthesis of the included studies was undertaken.
resultsOut of 425 articles identified, 22 quantitative articles and one qualitative article were included in the final review. Both the risk and protective factors obtained were categorized into three main domains: individual, family, and community factors. The individual risk factors identified were traits of high impulsivity; rebelliousness; emotional regulation impairment, low religious, pain catastrophic, homework completeness, total screen time and alexithymia; the experience of maltreatment or a negative upbringing; having psychiatric disorders such as conduct problems and major depressive disorder; previous e-cigarette exposure; behavioral addiction; low-perceived risk; high-perceived drug accessibility; and high-attitude to use synthetic drugs. The familial risk factors were prenatal maternal smoking; poor maternal psychological control; low parental education; negligence; poor supervision; uncontrolled pocket money; and the presence of substance-using family members. One community risk factor reported was having peers who abuse drugs. The protective factors determined were individual traits of optimism; a high level of mindfulness; having social phobia; having strong beliefs against substance abuse; the desire to maintain one's health; high paternal awareness of drug abuse; school connectedness; structured activity and having strong religious beliefs.
conclusionThe outcomes of this review suggest a complex interaction between a multitude of factors influencing adolescent drug abuse. Therefore, successful adolescent drug abuse prevention programs will require extensive work at all levels of domains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.