Trial reportBMC anesthesiology2021
High-protein intake and early exercise in adult intensive care patients: a prospective, randomized controlled trial to evaluate the impact on functional outcomes.
Trial report in BMC anesthesiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03469882 (High Protein Intake and Early Exercise in Adult Intensive Care Patients), which is not on this map. Cited by 32 papers, 12 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
High Protein Intake and Early Exercise in Adult Intensive Care Patients: Impact on Functional Outcomes. A Randomized Controlled Phase II Trial.
Who cites it
32 citing papers in PubMed, 12 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Korean clinical practice guidelines for rehabilitation in critically ill patients and post-intensive care syndrome.Acute and critical care · 2026Guideline
- The impact of protein intake on kidney adverse events in critically Ill patients: a systematic review and meta-analysis.International urology and nephrology · 2026Pooled it
- In-bed cycling for adult intensive care patients: A systematic review and meta-analysis.Medicine · 2026Pooled it
- Systematic review and meta-analysis of physical rehabilitation on functional recovery in critically ill patients.Frontiers in medicine · 2026Pooled it
- Comparative effectiveness of non-pharmacological interventions on health-related quality of life in ICU patients: a network meta-analysis.Frontiers in medicine · 2026Pooled it
- The intensive care medicine research agenda for the management of ICU acquired weakness: a multinational, interprofessional perspective.Intensive care medicine · 2025Pooled it
- Reporting of nutritional screening, status, and intake in trials of nutritional and physical rehabilitation following critical illness: a systematic review.The American journal of clinical nutrition · 2025Pooled it
- Guideline on positioning and early mobilisation in the critically ill by an expert panel.Intensive care medicine · 2024Guideline
- The effects of higher versus lower protein delivery in critically ill patients: an updated systematic review and meta-analysis of randomized controlled trials with trial sequential analysis.Critical care (London, England) · 2024Pooled it
- High-protein home parenteral nutrition in malnourished oncology patients: a systematic literature review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Pooled it
- A systematic review and meta-analysis of the clinimetric properties of the core outcome measurement instruments for clinical effectiveness trials of nutritional and metabolic interventions in critical illness (CONCISE).Critical care (London, England) · 2023Pooled it
- Nitrogen balance and outcomes in critically ill patients: A systematic review and meta-analysis.Frontiers in nutrition · 2022Pooled it
- Effects of protein, muscle rehabilitation and trunk neuromuscular electrostimulation in patients with prolonged mechanical ventilation: a prospective, randomized controlled pilot study.Annals of medicine · 2026Trial
- Combined intravenous bolus amino acid supplementation and mobilization on early muscle loss in critically ill adults: A randomized controlled trial.JPEN. Journal of parenteral and enteral nutrition · 2026Trial
- Association between protein dose in the early and late acute phases of critical illness and time-to-discharge-alive: A secondary analysis of a randomized clinical trial.JPEN. Journal of parenteral and enteral nutrition · 2026Trial
- Effects of a multilevel intervention of resistance training with or without beta-hydroxy-beta-methylbutyrate in medical ICU patients during entire hospitalisation: a four-arm multicentre randomised controlled trial.Critical care (London, England) · 2023Trial
- Trial
- Korean Clinical Practice Guidelines for Rehabilitation in Critically Ill Patients and Post-Intensive Care Syndrome.Annals of rehabilitation medicine · 2026Article
- Association of peripheral muscle mass and in-hospital mortality in mechanically ventilated critically ill children: a prospective observational study.European journal of pediatrics · 2026Observational
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe evaluated the efficacy of high protein intake and early exercise versus standard nutrition care and routine physiotherapy on the outcome of critically ill patients.
methodsWe randomized mechanically ventilated patients expected to stay in the intensive care unit (ICU) for 4 days. We used indirect calorimetry to determine energy expenditure and guide caloric provision to the patients randomized to the high protein and early exercise (HPE) group and the control group. Protein intakes were 1.48 g/kg/day and 1.19 g/kg/day medians respectively; while the former was submitted to two daily sessions of cycle ergometry exercise, the latter received routine physiotherapy. We evaluated the primary outcome physical component summary (PCS) score at 3 and 6 months) and the secondary outcomes (handgrip strength at ICU discharge and ICU and hospital mortality).
resultsWe analyzed 181 patients in the HPE (87) and control (94) group. There was no significant difference between groups in relation to calories received. However, the amount of protein received by the HPE group was significantly higher than that received by the control group (p < 0.0001). The PCS score was significantly higher in the HPE group at 3 months (p = 0.01) and 6 months (p = 0.01). The mortality was expressively higher in the control group. We found an independent association between age and 3-month PCS and that between age and group and 6-month PCS.
conclusionThis study showed that a high-protein intake and resistance exercise improved the physical quality of life and survival of critically ill patients.
trial registrationResearch Ethics Committee of Hospital São Domingos: Approval number 1.487.683, April 09, 2018. The study protocol was registered in ClinicalTrials.gov ( NCT03469882 , March 19,2018).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.