Evidence map›Paper›PMID 34773884›Full record

ArticleDrug and alcohol dependence2021

Testing the validity of the AUDIT-C and AUDIT-3 to detect unhealthy alcohol use among high-risk populations in Zambia: A secondary analysis from two randomized trials.

Sachi Inoue, Chipo Chitambi, Michael J Vinikoor, Tukiya Kanguya, Laura K Murray, Anjali Sharma, Geetanjali Chander, Ravi Paul, Mwamba M Mwenge, Saphira Munthali and 1 more

Open access · greenAbstract read
In one paragraph

Article in Drug and alcohol dependence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Sachi InoueDepartment of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA. Electronic address: sachi_inoue@hsph.harvard.edu.
Chipo ChitambiCentre for Infectious Disease Research in Zambia (CIDRZ), Lusaka, Zambia.
Michael J VinikoorUniversity of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Tukiya KanguyaCentre for Infectious Disease Research in Zambia (CIDRZ), Lusaka, Zambia.
Laura K MurrayDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Anjali SharmaCentre for Infectious Disease Research in Zambia (CIDRZ), Lusaka, Zambia.
Geetanjali ChanderJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Ravi PaulUniversity of Zambia School of Medicine, Lusaka, Zambia.
Mwamba M MwengeCentre for Infectious Disease Research in Zambia (CIDRZ), Lusaka, Zambia.
Saphira MunthaliCentre for Infectious Disease Research in Zambia (CIDRZ), Lusaka, Zambia.
Jeremy C KaneDepartment of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA.
Centre for Infectious Disease Research in Zambia · ZMColumbia University · USJohns Hopkins Medicine · USJohns Hopkins University · USUniversity of Alabama at Birmingham · USUniversity of Zambia · ZM

Funding

Mentoring and Patient Oriented Research at the Nexus of Unhealthy Alcohol Use and HIVK24AA027483 · NIAAA · UNIVERSITY OF WASHINGTON · PI GEETANJALI CHANDER · 2019 to 2026
$1.3M
Improving measurement of alcohol consumption among HIV-affected youth in sub-Saharan Africa: evaluation and implementation of biomarkersK01AA026523 · NIAAA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KANE, JEREMY CALVIN · 2020 to 2024
$881k
FEASIBILITY AND PRELIMINARY EFFECTIVENESS OF A TRANSDIAGNOSTIC COGNITIVE BEHAVIORAL THERAPY TREATMENT APPROACH FOR ALCOHOL MISUSE INTEGRATED WITHIN HIV CARE IN ZAMBIAR34AA027200 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI KANE, JEREMY CALVIN, VINIKOOR, MICHAEL JEFFREY · 2018 to 2020
$585k
NIAAA NIH HHS K01 AA026523NIAAA NIH HHS K24 AA027483NIAAA NIH HHS R34 AA027200
6 · The paper itself

Abstract

backgroundThis study evaluated the test characteristics of brief versions of the Alcohol Use Disorders Identification Test (AUDIT), the AUDIT-C and AUDIT-3, compared to the full AUDIT in populations with heavy drinking living in Zambia and compared differences in effect size estimates when using brief versions in clinical trials.

methodsData were obtained from two randomized trials of the Common Elements Treatment Approach (CETA) for reducing unhealthy alcohol use among adult couples and people living with HIV (PLWH) in Zambia. The full AUDIT was administered to participants at baseline and at 6- or 12-month follow-up. Sensitivity and specificity of the brief versions were calculated in comparison to the full AUDIT. Mixed effects regression models were estimated to calculate the effect sizes from the trials using the brief versions and these were compared to the originally calculated effect sizes using the full version.

resultsThe AUDIT-C performed well at cut-off ≥ 3 for both men (sensitivity: >80%; specificity: >76%) and women (sensitivity: >84%; specificity: >88%). The AUDIT-3 performed best at cut-off ≥ 1, but with comparatively reduced validity for men (sensitivity: >77%; specificity: ≥60%) and women (sensitivity: ≥72%; specificity: >62%). Effect sizes were different by up to 52% using the AUDIT-C and up to 60% for the AUDIT-3 compared to the AUDIT.

conclusionsThe AUDIT-C is recommended as a brief screening tool for community-based and clinic-based screening in Zambia among populations with high prevalence of unhealthy alcohol use. For research studies, the full AUDIT is recommended to calculate treatment effect.

Indexed as

AlcoholismAdultAlcohol DrinkingFemaleHumansMaleMass ScreeningRandomized Controlled Trials as TopicSurveys and QuestionnairesZambiaAUDITAUDIT-3AUDIT-CBrief screening toolUnhealthy alcohol useZambia

Identifiers

PMID34773884
PMCPMC8671251
OpenAlexW3211172943

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.