SynthesisPlacenta2022
Meta-analysis on COVID-19-pregnancy-related placental pathologies shows no specific pattern.
Synthesis in Placenta, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- COVID-19 in pregnant women: a systematic review and meta-analysis on the risk and prevalence of pregnancy loss.Human reproduction update · 2024Pooled it
- Pooled it
- Fetal vascular malperfusion and other placental lesions in relation to maternal SARS-CoV-2 exposure: a case-control study.Frontiers in medicine · 2026Article
- Maternal Coronavirus Disease 2019 Test Positivity and Neonatal Intensive Care Unit Outcomes for Infants Born Extremely Preterm.The Journal of pediatrics · 2026Article
- Morphological Changes in the Placenta of Patients with COVID-19 During Pregnancy.Diagnostics (Basel, Switzerland) · 2025Article
- Immunohistochemical Analysis of Placental Tissue of Women Infected with SARS-CoV-2 During Pregnancy-A Prospective Clinical Study.International journal of molecular sciences · 2025Article
- Maternal Obesity Modifies the Impact of Active SARS-CoV-2 Infection on Placental Pathology.Viruses · 2025Article
- SARS-CoV-2 Infection and Its Association with Maternal and Fetal Redox Status and Outcomes: A Prospective Clinical Study.Journal of clinical medicine · 2025Article
- Impact of COVID-19 disease on placental histopathology. PLAXAVID study.Histology and histopathology · 2024Observational
- Histological Alterations in Placentas of Pregnant Women with SARS-CoV-2 Infection: A Single-Center Case Series.Pathogens (Basel, Switzerland) · 2023Article
- Adverse Fetal Outcomes and Histopathology of Placentas Affected by COVID-19: A Report of Four Cases.Cureus · 2023Article
- Placental Pathology After SARS-CoV-2 Infection in the Pre-Variant of Concern, Alpha / Gamma, Delta, or Omicron Eras.International journal of surgical pathology · 2023Article
- Auditory Screening in Newborns after Maternal SARS-CoV-2 Infection: An Overview.Children (Basel, Switzerland) · 2023Review
- Diminished antiviral innate immune gene expression in the placenta following a maternal SARS-CoV-2 infection.American journal of obstetrics and gynecology · 2023Article
- SARS-CoV-2 variant-related abnormalities detected by prenatal MRI: a prospective case-control study.The Lancet regional health. Europe · 2023Article
- SARS-CoV-2 Transplacental Transmission: A Rare Occurrence? An Overview of the Protective Role of the Placenta.International journal of molecular sciences · 2023Review
- The influence of COVID-19 infection-associated immune response on the female reproductive system†.Biology of reproduction · 2023Article
- Review
- Article
- Functional consequences of SARS-CoV-2 infection in pregnant women, fetoplacental unit, and neonate.Biochimica et biophysica acta. Molecular basis of disease · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronavirus disease 2019 (COVID-19) pneumonia rarely occurs in pregnant women. Case reports indicate that fibrin and lymphohistiocytic lesions in placentas may be typical. However, a meta-analysis to clarify whether there is a COVID-19-associated pattern of placental lesions has not yet been conducted. Systematic literature search with meta-analysis of publications on 10 or more cases of pregnancy with SARS-CoV-2 infection and placenta examination (30 publications from 2019 to 2021; 1452 placenta cases) was performed. The meta-analysis did not reveal any COVID-19-specific placenta changes. The incidence of both vascular and inflammatory lesions was mainly comparable to that of non-COVID-19 pregnancies. Transplacental viral transmission is very rare and there are no typical placental changes. The most important prognostic factor seems to be maternal-fetal hypoxia in the context of pneumonia.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.