ArticleHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2022
Arterial Stiffness Alterations in Simulated Microgravity and Reactive Sledge as a Countermeasure.
Article in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 6 citations in OpenAlex.
- Physical exercise protects cardiovascular fitness in long-term spaceflight: what have we learned?Science China. Life sciences · 2026Review
- The effects of bed rest on cardiometabolic health: A systematic review and meta-analysis.Experimental physiology · 2026Article
- Long-term space missions' effects on the human organism: what we do know and what requires further research.Frontiers in physiology · 2024Review
- Space Biomedicine: A Unique Opportunity to Rethink the Relationships between Physics and Biology.Biomedicines · 2022Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
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Abstract
introductionExperiments during spaceflight and simulated microgravity as head-down tilt bedrest, demonstrated the role of arterial stiffness among others, in microgravity induced cardiovascular pathologies and emphasized the need for a robust countermeasure.
aimThe purpose of the present study was to evaluate the use of a new countermeasure, consisting of a high intensity Reactive Sledge (RSL) jumps training protocol, to counteract changes in arterial stiffness during long term head down tilt bedrest (LTBR).
methodsThe participants enrolled in the study were 23 male, healthy volunteers, aged between 20 and 45 years, subjected to LTBR for 60 days and randomly assigned either to a control (11) or to a training sledge (12) group using RSL 3-4 times per week, as a countermeasure. Recorded values were systolic and diastolic blood pressure, heart rate and the user's arterial stiffness index.
resultsCompared to baseline measurements, there was a deterioration in the values of arterial stiffness, systolic and diastolic blood pressure and heart rate, in both groups until day 35 of LTBR, interpreted as adaptation to the microgravity environment. From this day until the end of the experiment, arterial stiffness of the control group was constantly fluctuating, while constantly improving for the training group. During the recovery period, arterial stiffness values returned to the pre-experimental levels in both groups.
conclusionsOverall, arterial stiffness increased the longer the time spent in LTBR and the countermeasure was partially effective in preventing the observed phenomenon. German Clinical Trials Register (DRKS), DRKS00012946, September 18, 2017, retrospectively registered.
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