Evidence map›Paper›PMID 34773528›Full record

ArticleInternational journal of clinical oncology2022

Hsa_circ_0003195 as a biomarker for diagnosis and prognosis of gastric cancer.

Yibo Ma, Zhe Li, Dongnan Ma, Junming Guo, Weiliang Sun

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Article in International journal of clinical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yibo MaThe Affiliated People's Hospital, Ningbo University, Ningbo, China.
Zhe LiDepartment of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, China.
Dongnan MaDepartment of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, China.
Junming GuoThe Affiliated People's Hospital, Ningbo University, Ningbo, China. guojunming@nbu.edu.cn.ORCID http://orcid.org/0000-0003-2026-1075
Weiliang SunThe Affiliated People's Hospital, Ningbo University, Ningbo, China. msfsyk@163.com.

Funding

national natural science foundation of china 81772279
6 · The paper itself

Abstract

purposeRecent studies have shown that circular RNAs (circRNAs) are closely related to the occurrence and development of gastric cancer. In this paper, we analyzed the value of hsa_circ_0003195 in diagnosis and prognosis of gastric cancer.

methodsQuantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used to determine the level of hsa_circ_0003195 in 100 paired gastric cancer tissues and paracancerous tissues, 74 paired fasting plasma from gastric cancer patients before and 10 days after operation, and 74 fasting plasmas from healthy controls. A receiver operating characteristic (ROC) curve was generated to evaluate the diagnostic value. The survival analysis and Cox proportional-hazards model were used to evaluate the efficiency of hsa_circ_0003195 in predicting overall survival (OS) in patients with gastric cancer.

resultsThe expression of hsa_circ_0003195 was down-regulated in gastric cancer tissues and plasma from patients with gastric cancer. The expression level of hsa_circ_0003195 was correlated with differentiation, TNM stages, lymphatic metastasis, and distal metastasis. The area under the ROC curve (AUC) of tissue and plasma hsa_circ_0003195 was 0.684 and 0.695, respectively. The plasma hsa_circ_0003195 can be used as predictors of survival of patients with gastric cancer.

conclusionHsa_circ_0003195 may be a new diagnostic and prognostic marker of gastric cancer.

Indexed as

Stomach NeoplasmsBiomarkers, TumorHumansLymphatic MetastasisPrognosisRNA, CircularBiomarkers, TumorRNA, CircularBiomarkerCircular RNAGastric cancerHsa_circ_0003195Prognosis

Identifiers

PMID34773528

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.