SynthesisArchives of osteoporosis2021
Fracture prevalence in thalassemia: a systematic review and meta-analysis.
Synthesis in Archives of osteoporosis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The trial behind it
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Osteoporosis in children and adolescents with transfusion-dependent thalassemia and the diagnostic value of different indicators.BMC pediatrics · 2026Article
- Disproportionate Decline in Trabecular Bone Score Compared to Bone Mineral Density in Southeast Asian Patients with Thalassemia: A Matched Control Study.Calcified tissue international · 2026Article
- Association of osteoporosis and sarcopenia with fracture risk in transfusion-dependent thalassemia.Scientific reports · 2023Article
- Recent advancements in glucose dysregulation and pharmacological management of osteoporosis in transfusion-dependent thalassemia (TDT): an update of ICET-A (International Network of Clinicians for Endocrinopathies in Thalassemia and Adolescence Medicine).Acta bio-medica : Atenei Parmensis · 2023Review
- Current issues in evaluation and management of osteoporosis in Thailand.Osteoporosis and sarcopenia · 2023Review
- The role of opportunistic quantitative computed tomography in the evaluation of bone disease and risk of fracture in thalassemia major.European journal of haematology · 2022Article
- Non-Transfusion-Dependent Thalassemia: A Panoramic Review.Medicina (Kaunas, Lithuania) · 2022Review
- New Entity-Thalassemic Endocrine Disease: Major Beta-Thalassemia and Endocrine Involvement.Diagnostics (Basel, Switzerland) · 2022Review
- Analysis of circRNAs and circRNA-associated competing endogenous RNA networks in β-thalassemia.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultiple observational studies have reported high prevalence of fracture in patients with thalassemia. However, most of these studies have included limited number of patients, and only few of them have reported prevalence of fracture among patients with different types and severity of thalassemia.
objectiveThis systematic review and meta-analysis was conducted to summarize all available data of fracture prevalence among patients with thalassemia.
methodsA systematic review was conducted using EMBASE and MEDLINE databases from inception to June 2021 to determine studies that reported prevalence of fracture in thalassemia patients. The pooled prevalence with 95% confidence interval (95%CI) of fracture across studies was determined using a random-effect, generic inverse variance method.
resultsAfter two rounds of systematic review, a total of 25 studies with 4934 patients were included in the meta-analysis. The pooled prevalence of fracture among patients with thalassemia was 16% (95%CI, 15-17%, I
conclusionFracture is common in patients with thalassemia, and may be more prevalent in beta thalassemia and transfusion-dependent thalassemia than in alpha thalassemia and non-transfusion-dependent thalassemia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.