ArticleCommunications biology2021
Ionotropic receptors mediate nitrogenous waste avoidance in Drosophila melanogaster.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Shifts in bee diet breadths are associated with gene gains and losses and positive selection across olfactory receptors.G3 (Bethesda, Md.) · 2025Article
- Cholesterol taste avoidance ineLife · 2025Article
- Article
- Function and evolution of Ir52 receptors in mate detection in Drosophila.Current biology : CB · 2024Article
- Avoiding alkaline taste through ionotropic receptors.iScience · 2024Article
- The power of Drosophila genetics in studying insect toxicology and chemical ecology.Crop health · 2023Review
- The proton channel OTOP1 is a sensor for the taste of ammonium chloride.Nature communications · 2023Article
- Molecular Basis of Hexanoic Acid Taste inMolecules and cells · 2023Article
- The taste of vitamin C in Drosophila.EMBO reports · 2023Article
- Molecular sensors in the taste system of Drosophila.Genes & genomics · 2023Review
- Chemosensory detection of aversive concentrations of ammonia and basic volatile amines in insects.iScience · 2023Article
- An inhibitory mechanism for suppressing high salt intake in Drosophila.Chemical senses · 2023Article
- Protocol for binary food choice assays usingSTAR protocols · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ammonia and its amine-containing derivatives are widely found in natural decomposition byproducts. Here, we conducted biased chemoreceptor screening to investigate the mechanisms by which different concentrations of ammonium salt, urea, and putrescine in rotten fruits affect feeding and oviposition behavior. We identified three ionotropic receptors, including the two broadly required IR25a and IR76b receptors, as well as the narrowly tuned IR51b receptor. These three IRs were fundamental in eliciting avoidance against nitrogenous waste products, which is mediated by bitter-sensing gustatory receptor neurons (GRNs). The aversion of nitrogenous wastes was evaluated by the cellular requirement by expressing Kir2.1 and behavioral recoveries of the mutants in bitter-sensing GRNs. Furthermore, by conducting electrophysiology assays, we confirmed that ammonia compounds are aversive in taste as they directly activated bitter-sensing GRNs. Therefore, our findings provide insights into the ecological roles of IRs as a means to detect and avoid toxic nitrogenous waste products in nature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.