Evidence map›Paper›PMID 34773072›Full record

ArticleOncogene2022

MZF1 mediates oncogene-induced senescence by promoting the transcription of p16

Dan Wu, Hua Tan, Weijun Su, Dongmei Cheng, Guanwen Wang, Juan Wang, Ding A Ma, George M Dong, Peiqing Sun

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Oncogene, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
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  9. Article
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  11. Transcriptional regulation of INK4/ARF locus by cis and trans mechanisms.Frontiers in cell and developmental biology · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Dan Wu *Department of Cancer Biology, Comprehensive Cancer Center, Wake Forest Baptist Medical Center, Medical Center Blvd, Winston-, Salem, NC, 27157, USA.
Hua Tan *School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Weijun SuNankai University School of Medicine, Tianjin, China.
Dongmei ChengDepartment of Cancer Biology, Comprehensive Cancer Center, Wake Forest Baptist Medical Center, Medical Center Blvd, Winston-, Salem, NC, 27157, USA.
Guanwen WangDepartment of Cancer Biology, Comprehensive Cancer Center, Wake Forest Baptist Medical Center, Medical Center Blvd, Winston-, Salem, NC, 27157, USA.
Juan WangDepartment of Cancer Biology, Comprehensive Cancer Center, Wake Forest Baptist Medical Center, Medical Center Blvd, Winston-, Salem, NC, 27157, USA.
Ding A MaDepartment of Cancer Biology, Comprehensive Cancer Center, Wake Forest Baptist Medical Center, Medical Center Blvd, Winston-, Salem, NC, 27157, USA.
George M DongDepartment of Cancer Biology, Comprehensive Cancer Center, Wake Forest Baptist Medical Center, Medical Center Blvd, Winston-, Salem, NC, 27157, USA.
Peiqing SunDepartment of Cancer Biology, Comprehensive Cancer Center, Wake Forest Baptist Medical Center, Medical Center Blvd, Winston-, Salem, NC, 27157, USA. psun@wakehealth.edu.ORCID http://orcid.org/0000-0003-2255-6504
Atrium Health Wake Forest Baptist · USNankai University · CNThe University of Texas Health Science Center at Houston · US

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Tip60 in p38 and PRAK Mediated Oncogene-Induced Senescence and Tumor SuppressionR01CA131231 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUN, PEIQING · 2009 to 2018
$3.5M
The role of microRNA in oncogene-induced senescence and cancer developmentR01CA172115 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUN, PEIQING · 2014 to 2018
$1.8M
NCI NIH HHS P30 CA012197NCI NIH HHS R01 CA131231NCI NIH HHS R01 CA172115
6 · The paper itself

Abstract

Oncogene induced senescence is a tumor suppressing defense mechanism, in which the cell cycle-dependent protein kinase (CDK) inhibitor p16

Indexed as

AnimalsCells, CulturedCyclin-Dependent Kinase Inhibitor p16HumansKruppel-Like Transcription FactorsMiceMice, KnockoutOncogenesTranscription FactorsCyclin-Dependent Kinase Inhibitor p16Kruppel-Like Transcription FactorsMZF1 protein, humanTranscription Factors

Identifiers

PMID34773072
PMCPMC8758531
OpenAlexW3212622261

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.