ArticleBMC geriatrics2021
Functional decline in hospitalized older patients with coronavirus disease 2019: a retrospective cohort study.
Article in BMC geriatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Transitions in Functional Status and Frailty Among Post-Hospitalized COVID-19 Oldest-Old Adults: An 18-Month Follow-Up Study.Journal of clinical medicine · 2025Article
- Functional Capacity Among Brazilian Older Adults 12 Months After COVID-19 Infection: A Cross-Sectional Study.Journal of clinical medicine · 2024Article
- The relationship between comprehensive geriatric assessment on the pneumonia prognosis of older adults: a cross-sectional study.BMC pulmonary medicine · 2024Article
- Frailty in Older Adults with Dengue Fever.Medicina (Kaunas, Lithuania) · 2024Article
- Association Between Barthel's Index Change and All-Cause Mortality Among COVID-19 Pneumonia Patients Aged Over 80 Years Old: A Retrospective Cohort Study.Clinical interventions in aging · 2024Article
- Predictors of Basic Activity in Daily Living and Length of Hospitalization in Patients with COVID-19.Healthcare (Basel, Switzerland) · 2022Article
- Functional decline, long term symptoms and course of frailty at 3-months follow-up in COVID-19 older survivors, a prospective observational cohort study.BMC geriatrics · 2022Observational
- Functional Decline in COVID-19 Older Survivors Compared to Other Pneumonia Patients, a Case Control Study.The journal of nutrition, health & aging · 2022Article
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Authors and funding
2 authors.
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Abstract
backgroundThis study aimed to determine the frequency of functional decline and to identify the factors related to a greater risk of functional decline among hospitalized older patients with coronavirus disease 2019 (COVID-19).
methodsWe reviewed the medical records of patients aged over 65 years who were admitted to a tertiary care hospital for COVID-19 over 1 year from February 2020. We evaluated the proportion of functional decline, which was defined as a decrease in the Barthel Index score from before the onset of COVID-19 to discharge. Multivariable logistic regression analyses were performed to evaluate the associations between the demographic and clinical characteristics of patients at admission and a greater risk of functional decline. Two sensitivity analyses with different inclusion criteria were performed: one in patients without very severe functional decline before the onset of COVID-19 (i.e., limited to those with Barthel Index score ≥ 25), and the other with a composite outcome of functional decline and death at discharge.
resultsThe study included 132 patients with COVID-19; of these, 72 (54.5%) developed functional decline. The severity of COVID-19 did not differ between patients with functional decline and those without (P = 0.698). Factors associated with a greater risk of functional decline included female sex (adjusted odds ratio [aOR], 3.14; 95% confidence interval [CI], 1.25 to 7.94), Barthel Index score < 100 before the onset of COVID-19 (aOR, 13.73; 95% CI, 3.29 to 57.25), and elevation of plasma D-dimer level on admission (aOR, 3.19; 95% CI, 1.12 to 9.07). The sensitivity analyses yielded similar results to those of the main analysis.
conclusionsOver half of the older patients who recovered from COVID-19 developed functional decline at discharge from a tertiary care hospital in Japan. Baseline activities of daily living impairment, female sex, and elevated plasma D-dimer levels at admission were associated with a greater risk of functional decline.
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