Evidence map›Paper›PMID 34772205›Full record

ArticleMaterials (Basel, Switzerland)2021

Permeability of Ibuprofen in the Form of Free Acid and Salts of L-Valine Alkyl Esters from a Hydrogel Formulation through Strat-M™ Membrane and Human Skin.

Joanna Klebeko, Paula Ossowicz-Rupniewska, Anna Nowak, Ewa Janus, Wiktoria Duchnik, Urszula Adamiak-Giera, Łukasz Kucharski, Piotr Prowans, Jan Petriczko, Norbert Czapla and 3 more

Abstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
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  3. Frontiers in pharmacology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Joanna KlebekoDepartment of Chemical Organic Technology and Polymeric Materials, Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology in Szczecin, Piastów Ave. 42, 71-065 Szczecin, Poland.ORCID 0000-0002-3176-5511
Paula Ossowicz-RupniewskaDepartment of Chemical Organic Technology and Polymeric Materials, Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology in Szczecin, Piastów Ave. 42, 71-065 Szczecin, Poland.ORCID 0000-0002-2362-1809
Anna NowakDepartment of Cosmetic and Pharmaceutical Chemistry, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich Ave. 72, 70-111 Szczecin, Poland.
Ewa JanusDepartment of Chemical Organic Technology and Polymeric Materials, Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology in Szczecin, Piastów Ave. 42, 71-065 Szczecin, Poland.ORCID 0000-0002-7396-9424
Wiktoria DuchnikDepartment of Cosmetic and Pharmaceutical Chemistry, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich Ave. 72, 70-111 Szczecin, Poland.
Urszula Adamiak-GieraDepartment of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland.
Łukasz KucharskiDepartment of Cosmetic and Pharmaceutical Chemistry, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich Ave. 72, 70-111 Szczecin, Poland.ORCID 0000-0003-3295-5023
Piotr ProwansDepartment of Plastic, Endocrine and General Surgery, Pomeranian Medical University in Szczecin, Siedlecka 2, 72-010 Police, Poland.
Jan PetriczkoDepartment of Plastic, Endocrine and General Surgery, Pomeranian Medical University in Szczecin, Siedlecka 2, 72-010 Police, Poland.ORCID 0000-0002-1616-7564
Norbert CzaplaDepartment of Plastic, Endocrine and General Surgery, Pomeranian Medical University in Szczecin, Siedlecka 2, 72-010 Police, Poland.
Piotr BargielDepartment of Plastic, Endocrine and General Surgery, Pomeranian Medical University in Szczecin, Siedlecka 2, 72-010 Police, Poland.
Marta MarkowskaDepartment of Plastic, Endocrine and General Surgery, Pomeranian Medical University in Szczecin, Siedlecka 2, 72-010 Police, Poland.
Adam KlimowiczDepartment of Cosmetic and Pharmaceutical Chemistry, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich Ave. 72, 70-111 Szczecin, Poland.ORCID 0000-0001-6239-2853

Funding

National Centre for Research and Development LIDER/53/0225/L-11/19/NCBR/2020
6 · The paper itself

Abstract

This paper aimed to evaluate the effect of vehicle and chemical modifications of the structure of active compounds on the skin permeation and accumulation of ibuprofen [IBU]. In vitro permeation experiments were performed using human abdominal skin and Strat-M™ membrane. The HPLC method was used for quantitative determinations. The formulations tested were hydrogels containing IBU and its derivatives and commercial gel with ibuprofen. The results obtained indicate that Celugel

Indexed as

Celugel®derivatives of ibuprofenFranz cell diffusionhuman skinStrat-M™transdermal delivery system

Identifiers

PMID34772205
PMCPMC8588543

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.