Evidence map›Paper›PMID 34771690›Full record

ReviewCancers2021

A Focus on Regulatory Networks Linking MicroRNAs, Transcription Factors and Target Genes in Neuroblastoma.

Patrizia Perri, Mirco Ponzoni, Maria Valeria Corrias, Isabella Ceccherini, Simona Candiani, Tiziana Bachetti

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. MicroRNA-21 Expression as a Prognostic Biomarker in Oral Cancer: Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
    Pooled it
  3. Article
  4. Article
  5. Review
  6. Enhancer regulation in cancer: from epigenetics to mArchives of pharmacal research · 2025
    Review
  7. Review
  8. Review
  9. Decoding the Epigenome of Breast Cancer.International journal of molecular sciences · 2025
    Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. The Role of Estrogen in Brain MicroRNAs Regulation.Advanced pharmaceutical bulletin · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Patrizia PerriLaboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.ORCID 0000-0003-2538-8278
Mirco PonzoniLaboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.ORCID 0000-0002-6164-4286
Maria Valeria CorriasLaboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.ORCID 0000-0002-7316-0772
Isabella CeccheriniLaboratory of Genetics and Genomics of Rare Diseases, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Simona CandianiDepartment of Earth, Environment and Life Sciences, University of Genoa, 16132 Genoa, Italy.
Tiziana BachettiLaboratory of Genetics and Genomics of Rare Diseases, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Istituto Giannina Gaslini · ITUniversity of Genoa · IT

Funding

Associazione Italiana Sindrome da Ipoventilazione Centrale Congenita AISICC grant to TBMinistero della Salute "Ricerca Corrente 2021" to IRCCS Istituto Giannina Gaslini" RC 2021"Ministero della Salute "Ricerca Finalizzata 5 per mille" 2021 RF 2021 to MP
6 · The paper itself

Abstract

Neuroblastoma (NB) is a tumor of the peripheral sympathetic nervous system that substantially contributes to childhood cancer mortality. NB originates from neural crest cells (NCCs) undergoing a defective sympathetic neuronal differentiation and although the starting events leading to the development of NB remain to be fully elucidated, the master role of genetic alterations in key oncogenes has been ascertained: (1) amplification and/or over-expression of

Indexed as

ALKlet-7LIN28BmicroRNAsmiR-204miR-34MYCNneuroblastomaPHOX2Btranscription factors

Identifiers

PMID34771690
PMCPMC8582685
OpenAlexW3210074110

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.