Evidence map›Paper›PMID 34771659›Full record

ArticleCancers2021

3D-Printed Replica and Porcine Explants for Pre-Clinical Optimization of Endoscopic Tumor Treatment by Magnetic Targeting.

Anjali A Roeth, Ian Garretson, Maja Beltz, Till Herbold, Maximilian Schulze-Hagen, Sebastian Quaisser, Alex Georgens, Dirk Reith, Ioana Slabu, Christian D Klink and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anjali A RoethDepartment of General, Visceral and Transplant Surgery, RWTH Aachen University Hospital, 52074Aachen, Germany.ORCID 0000-0002-1670-7487
Ian GarretsonDepartment of Mechanical and Aerospace Engineering, University of California Davis, Davis, CA 95616, USA.
Maja BeltzDepartment of Mechanical and Aerospace Engineering, University of California Davis, Davis, CA 95616, USA.
Till HerboldDepartment of General, Visceral and Transplant Surgery, RWTH Aachen University Hospital, 52074Aachen, Germany.
Maximilian Schulze-HagenDepartment of Diagnostic and Interventional Radiology, RWTH Aachen University Hospital, 52074 Aachen, Germany.ORCID 0000-0002-9182-2688
Sebastian QuaisserDepartment of Mechanical and Aerospace Engineering, University of California Davis, Davis, CA 95616, USA.
Alex GeorgensDepartment of Mechanical and Aerospace Engineering, University of California Davis, Davis, CA 95616, USA.ORCID 0000-0003-2269-0199
Dirk ReithDepartment of Electrical and Mechanical Engineering, Bonn-Rhein-Sieg University of Applied Sciences, 53757 Sankt Augustin, Germany.ORCID 0000-0003-1480-6745
Ioana SlabuInstitute of Applied Medical Engineering, Helmholtz-Institute Aachen, RWTH Aachen University, 52062 Aachen, Germany.ORCID 0000-0002-8945-4310
Christian D KlinkDepartment of General, Visceral and Transplant Surgery, RWTH Aachen University Hospital, 52074Aachen, Germany.
Ulf P NeumannDepartment of General, Visceral and Transplant Surgery, RWTH Aachen University Hospital, 52074Aachen, Germany.
Barbara S LinkeDepartment of Mechanical and Aerospace Engineering, University of California Davis, Davis, CA 95616, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnimal models have limitations in cancer research, especially regarding anatomy-specific questions. An example is the exact endoscopic placement of magnetic field traps for the targeting of therapeutic nanoparticles. Three-dimensional-printed human replicas may be used to overcome these pitfalls.

methodsWe developed a transparent method to fabricate a patient-specific replica, allowing for a broad scope of application. As an example, we then additively manufactured the relevant organs of a patient with locally advanced pancreatic ductal adenocarcinoma. We performed experimental design investigations for a magnetic field trap and explored the best fixation methods on an explanted porcine stomach wall.

resultsWe describe in detail the eight-step development of a 3D replica from CT data. To guide further users in their decisions, a morphologic box was created. Endoscopies were performed on the replica and the resulting magnetic field was investigated. The best fixation method to hold the magnetic field traps stably in place was the fixation of loops at the stomach wall with endoscopic single-use clips.

conclusionsUsing only open access software, the developed method may be used for a variety of cancer-related research questions. A detailed description of the workflow allows one to produce a 3D replica for research or training purposes at low costs.

Indexed as

3D printingdigital manufacturingendoscopymagnetic hyperthermiamagnetic nanoparticlesmodelspancreatic cancerreplica

Identifiers

PMID34771659
PMCPMC8583102

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.