Evidence map›Paper›PMID 34771646›Full record

ArticleCancers2021

Towards Raman-Based Screening of Acute Lymphoblastic Leukemia-Type B (B-ALL) Subtypes.

Patrycja Leszczenko, Aleksandra Borek-Dorosz, Anna Maria Nowakowska, Adriana Adamczyk, Sviatlana Kashyrskaya, Justyna Jakubowska, Marta Ząbczyńska, Agata Pastorczak, Kinga Ostrowska, Malgorzata Baranska and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

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  10. Advances in the application of Raman spectroscopy in haematological tumours.Frontiers in bioengineering and biotechnology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Patrycja LeszczenkoFaculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland.ORCID 0000-0002-1422-6639
Aleksandra Borek-DoroszFaculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland.
Anna Maria NowakowskaFaculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland.ORCID 0000-0002-4585-1525
Adriana AdamczykFaculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland.
Sviatlana KashyrskayaFaculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland.
Justyna JakubowskaDepartment of Pediatrics, Oncology and Hematology, Medical University of Lodz, Sporna 36/50, 91-738 Lodz, Poland.
Marta ZąbczyńskaDepartment of Pediatrics, Oncology and Hematology, Medical University of Lodz, Sporna 36/50, 91-738 Lodz, Poland.ORCID 0000-0002-5014-6011
Agata PastorczakDepartment of Pediatrics, Oncology and Hematology, Medical University of Lodz, Sporna 36/50, 91-738 Lodz, Poland.
Kinga OstrowskaDepartment of Pediatrics, Oncology and Hematology, Medical University of Lodz, Sporna 36/50, 91-738 Lodz, Poland.ORCID 0000-0002-6235-7270
Malgorzata BaranskaFaculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland.ORCID 0000-0001-8826-3144
Katarzyna Maria MarzecLukasiewicz Research Network-Krakow Institute of Technology, Zakopiańska 73, 30-418 Krakow, Poland.
Katarzyna MajznerFaculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland.
Jagiellonian University · PLMedical University of Lodz · PLLukasiewicz Research Network - Krakow Institute of Technology · PL

Funding

Foundation for Polish Science POIR.04.04.00-00-16ED/18-00
6 · The paper itself

Abstract

Acute lymphoblastic leukemia (ALL) is the most common type of malignant neoplasms in the pediatric population. B-cell precursor ALLs (BCP-ALLs) are derived from the progenitors of B lymphocytes. Traditionally, risk factors stratifying therapy in ALL patients included age at diagnosis, initial leukocytosis, and the response to chemotherapy. Currently, treatment intensity is modified according to the presence of specific gene alterations in the leukemic genome. Raman imaging is a promising diagnostic tool, which enables the molecular characterization of cells and differentiation of subtypes of leukemia in clinical samples. This study aimed to characterize and distinguish cells isolated from the bone marrow of patients suffering from three subtypes of BCP-ALL, defined by gene rearrangements, i.e.,

Indexed as

acute lymphoblastic leukemia (ALL)BCR-ABL1chemometric techniquesfusion genesRaman spectroscopyTCF-PBX1TEL-AML1

Identifiers

PMID34771646
PMCPMC8582787
OpenAlexW3210487765

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.