ReviewCancers2021
Performance of Contrast-Enhanced Ultrasound in Thyroid Nodules: Review of Current State and Future Perspectives.
Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06146764 (Contrast-enhanced Ultrasound Improves the Diagnostic Performance of Sonographic Risk Stratification System of Thyroid Carcinoma), which is not on this map. Cited by 53 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Contrast-enhanced Ultrasound Improves the Diagnostic Performance of Sonographic Risk Stratification System of Thyroid Carcinoma: Comparison Between Integrated Scoring Method and Up-and-down Scoring Method
Who cites it
53 citing papers in PubMed, 3 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Diagnostic value of contrast-enhanced ultrasound combined with other imaging techniques in differentiating benign and malignant thyroid nodules: a network meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Malignant Risk Assessment of Cystic-solid Thyroid Nodules Based on Multimodal Ultrasound Features: A Systematic Review and Meta-analysis.Current medical imaging · 2025Pooled it
- Accuracy of Ultrasound Diagnosis of Benign and Malignant Thyroid Nodules: A Systematic Review and Meta-Analysis.International journal of clinical practice · 2022Pooled it
- Contrast-enhanced ultrasound-based energy response phenotyping in thyroid nodule ablation: identifying heterogeneous subgroups via latent class analysis.Quantitative imaging in medicine and surgery · 2026Article
- Synthesize contrast-enhanced ultrasound image of thyroid nodules via generative adversarial networks.European radiology · 2026Article
- Real-Time In Vivo Cellular-Level Imaging During Puncture.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Optimized dual-source dual-energy computed tomography nomogram model integrating background normalization improves solid thyroid nodules diagnosis.Gland surgery · 2026Article
- Barriers to the Broader Use of Contrast-Enhanced Ultrasound in Saudi Healthcare and Medical Research.Ultrasound international open · 2026Article
- Efficiency of 2017 ACR-TIRADS combined with contrast-enhanced ultrasound in diagnosing thyroid malignant nodules.Frontiers in endocrinology · 2026Article
- Quantitative Ultrasound Grayscale Analysis and Size of Benign and Malignant Solid Thyroid Nodules.Tomography (Ann Arbor, Mich.) · 2025Article
- Preoperative multiparametric ultrasound for the prediction of central lymph node metastasis in papillary thyroid carcinoma.Quantitative imaging in medicine and surgery · 2025Article
- Multimodal ultrasound to predict central cervical lymph node metastasis in clinically lymph node-negative differentiated thyroid carcinomas: a two-center retrospective study.Gland surgery · 2025Article
- The combined detection of aspiration biopsy, computed tomography and BRAFV600E gene has high diagnostic value for papillary thyroid carcinoma.Archives of endocrinology and metabolism · 2025Article
- Unusual nodular goiter with recurrent laryngeal nerve palsy due to severe degeneration caused by intense chronic inflammation: a case report with histopathological evidence and review of the literature.BMC endocrine disorders · 2025Review
- Contrast-enhanced ultrasound combined with shear wave elastography in the diagnosis of C-TIRADS category 4 thyroid nodules.Quantitative imaging in medicine and surgery · 2025Article
- Comparing ChatGPT 4.0's Performance in Interpreting Thyroid Nodule Ultrasound Reports Using ACR-TI-RADS 2017: Analysis Across Different Levels of Ultrasound User Experience.Diagnostics (Basel, Switzerland) · 2025Article
- Role of Ultrasound Elastography and Contrast-Enhanced Ultrasound (CEUS) in Diagnosis and Management of Malignant Thyroid Nodules-An Update.Diagnostics (Basel, Switzerland) · 2025Review
- Comparison of the efficacy and impact on coagulation function of different rituximab dosage regimens in the treatment of membranous nephropathy.American journal of translational research · 2025Article
- Mapping the Evolution of Thyroid Ultrasound Research: A 30-year Bibliometric AnalysisCurrent medical imaging · 2025Review
- Ultrasound radiomics and genomics improve the diagnosis of cytologically indeterminate thyroid nodules.Frontiers in endocrinology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ultrasound has been established as a baseline imaging technique for thyroid nodules. The main advantage of adding CEUS is the ability to assess the sequence and intensity of vascular perfusion and hemodynamics in the thyroid nodule, thus providing real-time characterization of nodule features, considered a valuable new approach in the determination of benign vs. malignant nodules. Original studies, reviews and six meta-analyses were included in this article. A total of 624 studies were retrieved, and 107 were included in the study. As recognized for thyroid nodule malignancy risk stratification by US, for acceptable accuracy in malignancy a combination of several CEUS parameters should be applied: hypo-enhancement, heterogeneous, peripheral irregular enhancement in combination with internal enhancement patterns, and slow wash-in and wash-out curve lower than in normal thyroid tissue. In contrast, homogeneous, intense enhancement with smooth rim enhancement and "fast-in and slow-out" are indicative of the benignity of the thyroid nodule. Even though overlapping features require standardization, with further research, CEUS may achieve reliable performance in detecting or excluding thyroid cancer. It can also play an operative role in guiding ablation procedures of benign and malignant thyroid nodules and metastatic lymph nodes, and providing accurate follow-up imaging to assess treatment efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.