Evidence map›Paper›PMID 34771598›Full record

ArticleCancers2021

The Associations between Perioperative Blood Transfusion and Long-Term Outcomes after Stomach Cancer Surgery.

Fu-Kai Hsu, Wen-Kuei Chang, Kuan-Ju Lin, Chun-Yu Liu, Wen-Liang Fang, Kuang-Yi Chang

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
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  6. Article
  7. Association of miR-338-3p with survival outcomes in gastric cancer patients who received peri-operative blood transfusion.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Fu-Kai HsuDepartment of Anesthesiology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Rd, Taipei 112201, Taiwan.
Wen-Kuei ChangDepartment of Anesthesiology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Rd, Taipei 112201, Taiwan.
Kuan-Ju LinDepartment of Anesthesiology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Rd, Taipei 112201, Taiwan.
Chun-Yu LiuSchool of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.ORCID 0000-0003-2336-4731
Wen-Liang FangSchool of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
Kuang-Yi ChangDepartment of Anesthesiology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Rd, Taipei 112201, Taiwan.
National Yang Ming Chiao Tung University · TW

Funding

Anesthesiology Research and Development Foundation, Taipei, Taiwan V109C-063Ministry of Science and Technology, Taiwan MOST109-2511-H-075-003-MY2Taipei Veterans General Hospital V109C-063Yen Tjing Ling Medical Foundation CI-109-29
6 · The paper itself

Abstract

backgroundWhether perioperative packed red blood cell (pRBC) transfusion is associated with inferior long-term outcomes after stomach cancer surgery remains controversial.

methodsThis research used a retrospective cohort study. Patients with stage I~III stomach cancer undergoing tumor resection were collected at a tertiary medical center. Patient characteristics, surgical features and pathologic findings were gathered from an electronic medical chart review. The associations of perioperative pRBC transfusion with postoperative disease-free and overall survivals were evaluated using Cox regression analysis with an inverse probability of treatment weighting (IPTW). Restricted cubic spline functions were employed to characterize dose-response relationships between the amount of transfusion and cancer outcomes after surgery.

resultsAmong the 569 patients, 160 (28.1%) received perioperative pRBC transfusion. Perioperative transfusion was associated with worse disease-free survival (IPTW adjusted HR: 1.42, 95% CI: 1.18-1.71,

conclusionsPerioperative pRBC transfusion was associated with worse disease-free and overall survival after stomach cancer surgery, and strategies aiming to minimize perioperative transfusion exposure should be further considered to reduce the potential risk.

Indexed as

blood transfusiondisease-free survivaldose-responsestomach neoplasmssurvival analysis

Identifiers

PMID34771598
PMCPMC8582361
OpenAlexW3210618143

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.