Evidence map›Paper›PMID 34771586›Full record

ArticleCancers2021

Can Conization Specimens Predict Sentinel Lymph Node Status in Early-Stage Cervical Cancer? A SENTICOL Group Study.

Vincent Balaya, Benedetta Guani, Julie Mereaux, Laurent Magaud, Basile Pache, Hélène Bonsang-Kitzis, Charlotte Ngô, David Desseauve, Patrice Mathevet, Fabrice Lécuru and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vincent BalayaGynecology Department, Centre Hospitalo-Universitaire Vaudois, 1011 Lausanne, Switzerland.ORCID 0000-0002-7561-239X
Benedetta GuaniGynecology Department, Centre Hospitalo-Universitaire Vaudois, 1011 Lausanne, Switzerland.ORCID 0000-0003-4498-3734
Julie MereauxBreast, Gynecology and Reconstructive Surgery Unit, Curie Institute, 75005 Paris, France.
Laurent MagaudClinical Research and Epidemiology Department, Public Health Center, Hospices Civils de Lyon, F-69003 Lyon, France.ORCID 0000-0002-2973-410X
Basile PacheGynecology Department, Centre Hospitalo-Universitaire Vaudois, 1011 Lausanne, Switzerland.ORCID 0000-0003-0969-7345
Hélène Bonsang-KitzisGynecological and Breast Surgery and Cancerology Center, RAMSAY-Générale de Santé, Hôpital Privé des Peupliers, 75013 Paris, France.
Charlotte NgôGynecological and Breast Surgery and Cancerology Center, RAMSAY-Générale de Santé, Hôpital Privé des Peupliers, 75013 Paris, France.
David DesseauveGynecology Department, Centre Hospitalo-Universitaire Vaudois, 1011 Lausanne, Switzerland.
Patrice MathevetGynecology Department, Centre Hospitalo-Universitaire Vaudois, 1011 Lausanne, Switzerland.
Fabrice LécuruBreast, Gynecology and Reconstructive Surgery Unit, Curie Institute, 75005 Paris, France.
On Behalf Of The Senticol Group

Funding

French National Cancer Institute AOR 03063
6 · The paper itself

Abstract

backgroundThe prognosis of patients with cervical cancer is significantly worsened in case of lymph node involvement. The goal of this study was to determine whether pathologic features in conization specimens can predict the sentinel lymph node (SLN) status in early-stage cervical cancer.

methodsAn ancillary analysis of two prospective multicentric database on SLN biopsy for cervical cancer (SENTICOL I and II) was carried out. Patients with IA to IB2 2018 FIGO stage, who underwent preoperative conization before SLN biopsy were included.

resultsBetween January 2005 and July 2012, 161 patients from 25 French centers fulfilled the inclusion criteria. Macrometastases, micrometastases and Isolated tumor cells (ITCs) were found in 4 (2.5%), 6 (3.7%) and 5 (3.1%) patients respectively. Compared to negative SLN patients, patients with micrometastatic and macrometastatic SLN were more likely to have lymphovascular space invasion (LVSI) (60% vs. 29.5%,

conclusionsPatients with DSI < 10 mm and no LVSI in conization specimens had lower risk of micro- and macrometastatic SLN. In this subpopulation, full node dissection may be questionable in case of SLN unilateral detection.

Indexed as

cervical cancerconizationlymphovascular space invasionSENTICOLsentinel lymph nodestromal invasion

Identifiers

PMID34771586
PMCPMC8582355

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