Evidence map›Paper›PMID 34771567›Full record

ArticleCancers2021

MR-Guided Adaptive Radiotherapy for Head and Neck Cancer: Prospective Evaluation of Migration and Anatomical Changes of the Major Salivary Glands.

Janita E van Timmeren, Madalyne Chamberlain, Marta Bogowicz, Stefanie Ehrbar, Riccardo Dal Bello, Helena Garcia Schüler, Jérôme Krayenbuehl, Lotte Wilke, Nicolaus Andratschke, Matthias Guckenberger and 2 more

Abstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Janita E van TimmerenDepartment of Radiation Oncology, University Hospital Zurich and University of Zurich, 8091 Zurich, Switzerland.ORCID 0000-0002-8166-6853
Madalyne ChamberlainDepartment of Radiation Oncology, University Hospital Zurich and University of Zurich, 8091 Zurich, Switzerland.ORCID 0000-0002-4300-1973
Marta BogowiczDepartment of Radiation Oncology, University Hospital Zurich and University of Zurich, 8091 Zurich, Switzerland.
Stefanie EhrbarDepartment of Radiation Oncology, University Hospital Zurich and University of Zurich, 8091 Zurich, Switzerland.
Riccardo Dal BelloDepartment of Radiation Oncology, University Hospital Zurich and University of Zurich, 8091 Zurich, Switzerland.ORCID 0000-0002-8755-377X
Helena Garcia SchülerDepartment of Radiation Oncology, University Hospital Zurich and University of Zurich, 8091 Zurich, Switzerland.
Jérôme KrayenbuehlDepartment of Radiation Oncology, University Hospital Zurich and University of Zurich, 8091 Zurich, Switzerland.
Lotte WilkeDepartment of Radiation Oncology, University Hospital Zurich and University of Zurich, 8091 Zurich, Switzerland.
Nicolaus AndratschkeDepartment of Radiation Oncology, University Hospital Zurich and University of Zurich, 8091 Zurich, Switzerland.
Matthias GuckenbergerDepartment of Radiation Oncology, University Hospital Zurich and University of Zurich, 8091 Zurich, Switzerland.
Stephanie Tanadini-LangDepartment of Radiation Oncology, University Hospital Zurich and University of Zurich, 8091 Zurich, Switzerland.
Panagiotis BalermpasDepartment of Radiation Oncology, University Hospital Zurich and University of Zurich, 8091 Zurich, Switzerland.ORCID 0000-0001-5261-6446

Funding

ViewRay (United States) Statement of Work, 29Apr2020
6 · The paper itself

Abstract

The aim of this study was to quantify anatomical changes of parotids and submandibular glands and evaluate potential dosimetric advantages during weekly adaptive MR-guided radiotherapy (MRgRT) for the definitive treatment of head and neck cancer (HNC). The data and plans of 12 patients treated with bilateral intensity-modulated radiotherapy for HNC using MR-linac, with weekly offline adaptations, were prospectively evaluated. The positional and volumetric changes of the salivary glands were analyzed by manual segmentation in weekly MRI images and the dosimetric impact of these anatomical changes on the adapted treatment plans was assessed. The mean volume change in parotid and submandibular gland volume was -31.9% (

Indexed as

adaptive radiotherapyhead and neck cancerimage-guided radiotherapyMRI-linacparotid glandssubmandibular glands

Identifiers

PMID34771567
PMCPMC8582485

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.