Evidence map›Paper›PMID 34771561›Full record

ArticleCancers2021

Lymphoma-Associated Biomarkers Are Increased in Current Smokers in Twin Pairs Discordant for Smoking.

Jun Wang, David V Conti, Marta Epeldegui, Miina Ollikainen, Rachel F Tyndale, Amie Eunah Hwang, Larry Magpantay, Thomas McCulloch Mack, Otoniel Martinez-Maza, Jaakko Kaprio and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Jun WangDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
David V ContiDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Marta EpeldeguiDepartment of Obstetrics and Gynecology, AIDS Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-7605-5994
Miina OllikainenDepartment of Public Health, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.
Rachel F TyndaleCentre for Addiction and Mental Health, Departments of Pharmacology & Toxicology, and Psychiatry, University of Toronto, and Campbell Family Mental Health Research Institute, Toronto, ON M5S 1A8, Canada.ORCID 0000-0003-1297-2053
Amie Eunah HwangDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Larry MagpantayDepartment of Obstetrics and Gynecology, AIDS Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Thomas McCulloch MackDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Otoniel Martinez-MazaDepartment of Obstetrics and Gynecology, AIDS Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Jaakko KaprioDepartment of Public Health, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0002-3716-2455
Wendy CozenDepartment of Medicine, Division of Hematology-Oncology, School of Medicine, University of California Irvine, Orange, CA 92868, USA.
University of Southern California · USUniversity of California, Los Angeles · USUniversity of Helsinki · FICentre for Addiction and Mental Health · CAUniversity of California, Irvine · US

Funding

Academy of Finland 265240, 263278, 308248, 312073, 336823California Tobacco-Related Disease Program RT-01077H, 6RT-0354HCanada Excellence Research Chairs, Government of Canada 154294Centre for Addiction and Mental Health NASigrid Juselius Foundation NASTOP CANCER, Norris Comprehensive Cancer Center Foundation NA
6 · The paper itself

Abstract

Smoking is associated with a moderate increased risk of Hodgkin and follicular lymphoma. To understand why, we examined lymphoma-related biomarker levels among 134 smoking and non-smoking twins (67 pairs) ascertained from the Finnish Twin Cohort. Previously collected frozen serum samples were tested for cotinine to validate self-reported smoking history. In total, 27 immune biomarkers were assayed using the Luminex Multiplex platform (R & D Systems). Current and non-current smokers were defined by a serum cotinine concentration of >3.08 ng/mL and ≤3.08 ng/mL, respectively. Associations between biomarkers and smoking were assessed using linear mixed models to estimate beta coefficients and standard errors, adjusting for age, sex and twin pair as a random effect. There were 55 never smokers, 43 current smokers and 36 former smokers. CCL17/TARC, sgp130, haptoglobin, B-cell activating factor (BAFF) and monocyte chemoattractant protein-1 (MCP1) were significantly (

Indexed as

BAFFbiomarkerschemokinescytokinesfollicular lymphomaHodgkin lymphomaMCP1smokingspg130TARC/CCL17twins

Identifiers

PMID34771561
PMCPMC8582438
OpenAlexW3209172262

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.