Evidence map›Paper›PMID 34771558›Full record

ReviewCancers2021

Atlas of Lobular Breast Cancer Models: Challenges and Strategic Directions.

George Sflomos, Koen Schipper, Thijs Koorman, Amanda Fitzpatrick, Steffi Oesterreich, Adrian V Lee, Jos Jonkers, Valerie G Brunton, Matthias Christgen, Clare Isacke and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 47 citations in OpenAlex.

  1. Trial
  2. Toward targeted therapeutics for lobular breast cancer.The Journal of clinical investigation · 2026
    Review
  3. Article
  4. Article
  5. Article
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  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. bioRxiv : the preprint server for biology · 2025
    Article
  14. Article
  15. Article
  16. Targeting Tumor Heterogeneity by Breaking a Stem Cell and Epithelial Niche Interaction Loop.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 5 countries.

George SflomosISREC-Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.ORCID 0000-0003-2972-0549
Koen SchipperThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.ORCID 0000-0002-4004-3318
Thijs KoormanDepartment of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Amanda FitzpatrickThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.
Steffi OesterreichDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0002-2537-6923
Adrian V LeeDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Jos JonkersDivision of Molecular Pathology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.ORCID 0000-0002-9264-9792
Valerie G BruntonEdinburgh Cancer Research UK Centre, Institute of Genetics and Cancer, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XU, UK.
Matthias ChristgenInstitute of Pathology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.
Clare IsackeThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.
Patrick W B DerksenDepartment of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.ORCID 0000-0003-0732-7762
Cathrin BriskenISREC-Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Institute of Cancer Research · GBHeidelberg University · DEUniversity of Pittsburgh · USÉcole Polytechnique Fédérale de Lausanne · CHEdinburgh Cancer Research · GBMedizinische Hochschule Hannover · DEThe Netherlands Cancer Institute · NL

Funding

Developing and credentialing murine models of ILCR01CA252378 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Adrian V Lee, Steffi Oesterreich · 2021 to 2026
$3.0M
Cancer Research UK 24837Medical Research Council MR/P001564/1NCI NIH HHS R01 CA252378
6 · The paper itself

Abstract

Invasive lobular carcinoma (ILC) accounts for up to 15% of all breast cancer (BC) cases and responds well to endocrine treatment when estrogen receptor α-positive (ER

Indexed as

animal modelscell linesELBCCexperimental modelsGEMMinvasive lobular breast carcinomametastasisPDXtranslational researchtumor organoids

Identifiers

PMID34771558
PMCPMC8582475
OpenAlexW3209263200

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.