ReviewCancers2021
Sinistral Portal Hypertension after Pancreaticoduodenectomy with Splenic Vein Resection: Pathogenesis and Its Prevention.
Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Gastric venous congestion after pancreatic surgery: A systematic review, metanalysis and suggested protocol for assessment and management.Langenbeck's archives of surgery · 2026Pooled it
- nnU-Net-based CT segmentation of perigastric varices in sinistral portal hypertension: a multicenter study.Abdominal radiology (New York) · 2026Article
- Surgical Challenges Associated with Collateral Veins Formation in Pancreatic Cancer with Vein Resection.Annals of surgical oncology · 2026Article
- Endoscopic resolution of esophageal varices in a patient with IgG4-related disease: a case report.Frontiers in medicine · 2026Article
- Development of a nomogram for predicting pancreatic portal hypertension in patients with acute pancreatitis: a retrospective study.BMJ open gastroenterology · 2024Article
- Use of Vascular Shunt at the Time of Pancreatectomy with Venous Resection: A Systematic Review.Cancers · 2024Review
- Rupture of ectopic varices of the ascending colon occurring after pancreatic cancer surgery: A case report and literature review.DEN open · 2024Article
- Portal vein wedge resection and patch venoplasty with autologous vein grafts for hepatobiliary-pancreatic cancer.Surgical case reports · 2024Article
- Management of Sinistral Portal Hypertension after Pancreaticoduodenectomy.Digestive diseases (Basel, Switzerland) · 2024Review
- Varicose vein embolization and portal vein stenting in a patient with sinistral portal hypertension-induced gastrointestinal hemorrhage: a case report.Annals of medicine and surgery (2012) · 2024Article
- SplenectomyTherapeutic advances in gastroenterology · 2024Article
- Splenic Hilar Involvement and Sinistral Portal Hypertension in Unresectable Pancreatic Tail Cancer.Cancers · 2023Article
- Analysis of risk factors for acute pancreatitis complicated with pancreatic sinistral portal hypertension and construction of predictive model.Frontiers in physiology · 2023Article
- Article
- Application of Ultrasound Elastography in Assessing Portal Hypertension.Diagnostics (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To achieve curative resection for pancreatic cancer during pancreaticoduodenectomy (PD), extensive portal vein (PV) resection, including porto-mesenterico-splenic confluence (PMSC), may sometimes be necessary if the tumor is close to the portal venous system. Recently, this extended resection has been widely accepted in high-volume centers for pancreatic resection due to its favorable outcomes compared with non-operative treatment. However, in patients with long-term survival, sinistral portal hypertension (SPH) occurs as a late-onset postoperative complication. These patients present gastrointestinal varices due to congested venous flow from the spleen, which may cause critical variceal bleeding. Since the prognosis of patients with pancreatic cancer has improved, owing to the development of chemotherapy and surgical techniques, SPH is no longer a negligible matter in the field of pancreatic cancer surgery. This review clarifies the pathogenesis and frequency of SPH after PD through PMSC resection and discusses its prediction and prevention.
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