Evidence map›Paper›PMID 34771490›Full record

ArticleCancers2021

Assessment of Radiation-Induced Optic Neuropathy in a Multi-Institutional Cohort of Chordoma and Chondrosarcoma Patients Treated with Proton Therapy.

Andreas Köthe, Loïc Feuvret, Damien Charles Weber, Sairos Safai, Antony John Lomax, Giovanni Fattori

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Ophthalmic complications of radiotherapy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Andreas KötheCenter for Proton Therapy, Paul Scherrer Institute, 5232 Villigen, Switzerland.ORCID 0000-0003-2628-8754
Loïc FeuvretCenter for Proton Therapy, Institut Curie, 91400 Orsay, France.
Damien Charles WeberCenter for Proton Therapy, Paul Scherrer Institute, 5232 Villigen, Switzerland.
Sairos SafaiCenter for Proton Therapy, Paul Scherrer Institute, 5232 Villigen, Switzerland.
Antony John LomaxCenter for Proton Therapy, Paul Scherrer Institute, 5232 Villigen, Switzerland.
Giovanni FattoriCenter for Proton Therapy, Paul Scherrer Institute, 5232 Villigen, Switzerland.ORCID 0000-0002-7639-7759
Paul Scherrer Institute · CHSorbonne Université · FRUniversity Hospital of Bern · CH

Funding

Personalized Health and Related Technologies (PHRT - ETH Domain) 2018-223
6 · The paper itself

Abstract

Radiation-induced optic neuropathy (RION) is a rare side effect following radiation therapy involving the optic structures whose onset is, due to the low amount of available data, challenging to predict. We have analyzed a multi-institutional cohort including 289 skull-base cancer patients treated with proton therapy who all received >45 Gy

Indexed as

chondrosarcomachordomanormal tissue effectsNTCPoptic toxicityproton therapyRIONrisk factorsskull base

Identifiers

PMID34771490
PMCPMC8582447
OpenAlexW3208474150

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.