Evidence map›Paper›PMID 34771477›Full record

ArticleCancers2021

3p Arm Loss and Survival in Head and Neck Cancer: An Analysis of TCGA Dataset.

Hugh Andrew Jinwook Kim, Mushfiq Hassan Shaikh, Mark Lee, Peter Y F Zeng, Alana Sorgini, Temitope Akintola, Xiaoxiao Deng, Laura Jarycki, Halema Khan, Danielle MacNeil and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Interferon Epsilon Loss Is Elusive 9p21 Link to Immune-Cold Tumors, Resistant to Immune Checkpoint Therapy, and Endogenous CXCL9/10 Induction.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2025
    Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 2 countries.

Hugh Andrew Jinwook KimDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, ON N6A3K7, Canada.ORCID 0000-0002-8424-148X
Mushfiq Hassan ShaikhDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, ON N6A3K7, Canada.ORCID 0000-0001-9953-3939
Mark LeeMemorial Sloan Kettering Cancer Center, Department of Surgery, New York, NY 10065, USA.
Peter Y F ZengDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, ON N6A3K7, Canada.
Alana SorginiDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, ON N6A3K7, Canada.ORCID 0000-0002-4796-5286
Temitope AkintolaDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, ON N6A3K7, Canada.
Xiaoxiao DengDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, ON N6A3K7, Canada.ORCID 0000-0002-5258-6635
Laura JaryckiDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, ON N6A3K7, Canada.
Halema KhanDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, ON N6A3K7, Canada.
Danielle MacNeilDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, ON N6A3K7, Canada.
Mohammed Imran KhanDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, ON N6A3K7, Canada.ORCID 0000-0003-3020-1324
Adrian MendezDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, ON N6A3K7, Canada.
John YooDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, ON N6A3K7, Canada.
Kevin FungDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, ON N6A3K7, Canada.
Pencilla LangDepartment of Oncology, University of Western Ontario, London, ON N6A3K7, Canada.
David A PalmaDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, ON N6A3K7, Canada.
Krupal PatelMoffitt Cancer Center, Department of Otolaryngology, Tampa, FL 33612, USA.ORCID 0000-0002-2285-0386
Joe S MymrykDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, ON N6A3K7, Canada.ORCID 0000-0002-3521-8005
John W BarrettDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, ON N6A3K7, Canada.ORCID 0000-0003-3708-3834
Paul C BoutrosDepartment of Human Genetics, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0003-0553-7520
Luc G T MorrisMemorial Sloan Kettering Cancer Center, Department of Surgery, New York, NY 10065, USA.ORCID 0000-0002-4417-2280
Anthony C NicholsDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, ON N6A3K7, Canada.ORCID 0000-0002-0760-980X
Western University · CAMemorial Sloan Kettering Cancer Center · USMoffitt Cancer Center · USUniversity of California, Los Angeles · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
Identifying and targeting neoantigens in aggressive salivary carcinomasR01DE027738 · NIDCR · SLOAN-KETTERING INST CAN RESEARCH · PI CHAN, TIMOTHY AN-THY, HO, ALAN L. · 2018 to 2022
$2.8M
CIHR MOP 340674NCI NIH HHS P30 CA008748NIH HHS P30CA008748NIH HHS P30CA016042NIH HHS R01 DE027738
6 · The paper itself

Abstract

Loss of the 3p chromosome arm has previously been reported to be a biomarker of poorer outcome in both human papillomavirus (HPV)-positive and HPV-negative head and neck cancer. However, the precise operational measurement of 3p arm loss is unclear and the mutational profile associated with the event has not been thoroughly characterized. We downloaded the clinical, single nucleotide variation (SNV), copy number aberration (CNA), RNA sequencing, and reverse phase protein assay (RPPA) data from The Cancer Genome Atlas (TCGA) and The Cancer Proteome Atlas HNSCC cohorts. Survival data and hypoxia scores were downloaded from published studies. In addition, we report the inclusion of an independent Memorial Sloan Kettering cohort. We assessed the frequency of loci deletions across the 3p arm separately in HPV-positive and -negative disease. We found that deletions on chromosome 3p were almost exclusively an all or none event in the HPV-negative cohort; patients either had <1% or >97% of the arm deleted. 3p arm loss, defined as >97% deletion in HPV-positive patients and >50% in HPV-negative patients, had no impact on survival (

Indexed as

chromosome losscopy number alterationsgenomicshead and neck cancermutational status

Identifiers

PMID34771477
PMCPMC8582539
OpenAlexW3208915748

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.