Evidence map›Paper›PMID 34771452›Full record

ArticleCancers2021

Hepatic Arterial Infusion Chemotherapy with Cisplatin versus Sorafenib for Intrahepatic Advanced Hepatocellular Carcinoma: A Propensity Score-Matched Analysis.

Yuki Zaizen, Masahito Nakano, Kazuta Fukumori, Yoichi Yano, Kota Takaki, Takashi Niizeki, Kotaro Kuwaki, Masaru Fukahori, Takahiko Sakaue, Sohei Yoshimura and 10 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 1 institution in 1 country.

Yuki ZaizenDivision of Gastroenterology, Department of Medicine, School of Medicine, Kurume University, Kurume 830-0011, Japan.
Masahito NakanoDivision of Gastroenterology, Department of Medicine, School of Medicine, Kurume University, Kurume 830-0011, Japan.ORCID 0000-0002-3375-180X
Kazuta FukumoriDivision of Gastroenterology, Department of Medicine, School of Medicine, Kurume University, Kurume 830-0011, Japan.
Yoichi YanoDivision of Gastroenterology, Department of Medicine, Japan Community Health Care Organization, Saga Central Hospital, Saga 849-8522, Japan.
Kota TakakiDivision of Gastroenterology, Department of Medicine, School of Medicine, Kurume University, Kurume 830-0011, Japan.
Takashi NiizekiDivision of Gastroenterology, Department of Medicine, School of Medicine, Kurume University, Kurume 830-0011, Japan.
Kotaro KuwakiDivision of Gastroenterology, Department of Medicine, School of Medicine, Kurume University, Kurume 830-0011, Japan.
Masaru FukahoriDivision of Gastroenterology, Department of Medicine, School of Medicine, Kurume University, Kurume 830-0011, Japan.
Takahiko SakaueDivision of Gastroenterology, Department of Medicine, School of Medicine, Kurume University, Kurume 830-0011, Japan.
Sohei YoshimuraDivision of Gastroenterology, Department of Medicine, School of Medicine, Kurume University, Kurume 830-0011, Japan.
Mika NakazakiDivision of Gastroenterology, Department of Medicine, School of Medicine, Kurume University, Kurume 830-0011, Japan.
Ryoko KuromatsuDivision of Gastroenterology, Department of Medicine, School of Medicine, Kurume University, Kurume 830-0011, Japan.
Shusuke OkamuraDivision of Gastroenterology, Department of Medicine, School of Medicine, Kurume University, Kurume 830-0011, Japan.
Hideki IwamotoDivision of Gastroenterology, Department of Medicine, School of Medicine, Kurume University, Kurume 830-0011, Japan.
Shigeo ShimoseDivision of Gastroenterology, Department of Medicine, School of Medicine, Kurume University, Kurume 830-0011, Japan.ORCID 0000-0003-2068-8386
Tomotake ShironoDivision of Gastroenterology, Department of Medicine, School of Medicine, Kurume University, Kurume 830-0011, Japan.ORCID 0000-0002-2662-6779
Yu NodaDivision of Gastroenterology, Department of Medicine, School of Medicine, Kurume University, Kurume 830-0011, Japan.
Naoki KamachiDivision of Gastroenterology, Department of Medicine, School of Medicine, Kurume University, Kurume 830-0011, Japan.
Hironori KogaDivision of Gastroenterology, Department of Medicine, School of Medicine, Kurume University, Kurume 830-0011, Japan.ORCID 0000-0001-5814-9543
Takuji TorimuraDivision of Gastroenterology, Department of Medicine, School of Medicine, Kurume University, Kurume 830-0011, Japan.
Kurume University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Given that the outcome of hepatic arterial infusion chemotherapy (HAIC) with cisplatin for intrahepatic advanced hepatocellular carcinoma (HCC) is unclear, we aimed to compare prognostic factors for overall survival (OS) following HAIC with cisplatin versus sorafenib for intrahepatic advanced HCC using propensity score-matched analysis. We enrolled 331 patients with intrahepatic advanced HCC who received HAIC with cisplatin (n = 88) or sorafenib (n = 243) between June 2006 and March 2020. No significant difference was observed in OS between HAIC with cisplatin and sorafenib cohorts (median survival time [MST]: 14.0 vs. 12.3 months;

Indexed as

cisplatinhepatic arterial infusion chemotherapyhepatocellular carcinomamultikinase inhibitorpropensity score-matched analysisrisk factorssorafenib

Identifiers

PMID34771452
PMCPMC8582478
OpenAlexW3207368820

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.