ReviewCancers2021
Adrenocortical Carcinoma in Childhood: A Systematic Review.
Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Spotting childhood abdominal tumours: a systematic review and meta-analysis of the clinical presentation.Archives of disease in childhood · 2026Pooled it
- Conservative management of perinatal adrenal masses in a single institution retrospective study.Discover oncology · 2026Article
- Surgical Management and Outcomes in Pediatric Adrenocortical Carcinoma: A Pediatric Surgical Oncology Research Collaborative Study.Annals of surgical oncology · 2026Article
- Functional and behavioral outcomes in pediatric adrenal carcinoma under mitotane therapy: a caregiver-reported pilot study.Endocrine oncology (Bristol, England) · 2026Article
- Three cases of pediatric adrenocortical carcinoma with intermediate malignant potential: a case report with literature review.AME case reports · 2026Article
- Identification and validation of susceptibility modules and hub genes of adrenocortical carcinoma through WGCNA and machine learning.Discover oncology · 2025Article
- Inflammation-based score in pediatric adrenocortical carcinoma.Endocrine-related cancer · 2025Article
- Adrenal Tumors in Children and Adolescents in Sweden: A Register-Based Study Covering 15 Years.Journal of the Endocrine Society · 2025Article
- Pediatric adrenocortical carcinoma complicated by uric acid nephrolithiasis: a unique case report.BMC urology · 2025Article
- Nutritional support in children treated for advanced adrenocortical carcinoma.Pediatric surgery international · 2025Observational
- Adrenocortical neoplasm in a 2-year-old child: Clinical approach and diagnostic imaging.Radiology case reports · 2024Article
- Editorial: Rare forms of pediatric adrenal disorders: beyond congenital adrenal hyperplasia due to 21-hydroxylase deficiency.Frontiers in endocrinology · 2024Article
- An Asymptomatic, Ectopic Mass as a Presentation of Adrenocortical Carcinoma Due to a Novel GermlineChildren (Basel, Switzerland) · 2023Article
- Locally Advanced Adrenocortical Carcinoma in Children and Adolescents-Enigmatic and Challenging Cases.Cancers · 2023Article
- Cortisol-Producing Adrenocortical Carcinoma Presenting with Hypertensive Emergency.The American journal of case reports · 2023Article
- Article
- Retrospective Analysis of Prognostic Factors in Pediatric Patients with Adrenocortical Tumor from Unique Tertiary Center with Long-Term Follow-Up.Journal of clinical medicine · 2022Review
- Radiotherapy for pediatric adrenocortical carcinoma - Review of the literature.Clinical and translational radiation oncology · 2022Review
- Adrenalectomies in children and adolescents in Germany - a diagnose related groups based analysis from 2009-2017.Frontiers in endocrinology · 2022Article
- Adjuvant therapy in adrenocortical carcinoma: prognostic factors and treatment options.Endocrine oncology (Bristol, England) · 2022Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adrenocortical tumors are rare in children. This systematic review summarizes the published evidence on pediatric adrenocortical carcinoma (ACC) to provide a basis for a better understanding of the disease, investigate new molecular biomarkers and therapeutic targets, and define which patients may benefit from a more aggressive therapeutic approach. We included 137 studies with 3680 ACC patients (~65% female) in our analysis. We found no randomized controlled trials, so this review mainly reflects retrospective data. Due to a specific mutation in the TP53 gene in ~80% of Brazilian patients, that cohort was analyzed separately from series from other countries. Hormone analysis was described in 2569 of the 2874 patients (89%). Most patients were diagnosed with localized disease, whereas 23% had metastasis at primary diagnosis. Only 72% of the patients achieved complete resection. In 334 children (23%), recurrent disease was reported: 81%-local recurrence, 19% (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.