Evidence map›Paper›PMID 34771424›Full record

ArticleCancers2021

Photodynamic Priming Improves the Anti-Migratory Activity of Prostaglandin E Receptor 4 Antagonist in Cancer Cells In Vitro.

Aaron J Sorrin, Cindy Liu, Julia Cicalo, Jocelyn Reader, Daniel Najafali, Yuji Zhang, Dana M Roque, Huang-Chiao Huang

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Exploiting Unique Features of Microneedles to Modulate Immunity.Advanced materials (Deerfield Beach, Fla.) · 2023
    Review
  6. Article
  7. Critical PDT theory II: Current concepts and indications.Photodiagnosis and photodynamic therapy · 2022
    Article
  8. Critical PDT Theory III: Events at the Molecular and Cellular Level.International journal of molecular sciences · 2022
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Aaron J SorrinFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Cindy LiuFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Julia CicaloFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Jocelyn ReaderDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-9971-9087
Daniel NajafaliFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.ORCID 0000-0003-1509-9229
Yuji ZhangUniversity of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD 21201, USA.
Dana M RoqueDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-7098-6376
Huang-Chiao HuangFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.ORCID 0000-0002-5406-0733
University of Maryland, Baltimore · USUniversity of Maryland, College Park · US

Funding

Addressing Chemoresistance in Pancreatic and Ovarian Cancers: Photodynamic Priming and Repurposing of Tetracyclines using Targeted Photo-Activable Multi-Inhibitor LiposomeR01CA260340 · NCI · UNIV OF MARYLAND, COLLEGE PARK · PI HUANG, HUANG CHIAO · 2021 to 2025
$3.2M
Foundation for Women's Cancer Caring Together, NY, Ovarian Cancer Research grantNCI NIH HHS R01 CA260340NIH HHS R01CA260340
6 · The paper itself

Abstract

The combination of photodynamic agents and biological inhibitors is rapidly gaining attention for its promise and approval in treating advanced cancer. The activity of photodynamic treatment is mainly governed by the formation of reactive oxygen species upon light activation of photosensitizers. Exposure to reactive oxygen species above a threshold dose can induce cellular damage and cancer cell death, while the surviving cancer cells are "photodynamically primed", or sensitized, to respond better to other drugs and biological treatments. Here, we report a new combination regimen of photodynamic priming (PDP) and prostaglandin E

Indexed as

antibody-drug conjugateovarian cancerphotodynamic therapyphotoimmunotherapyprostaglandin inhibitor

Identifiers

PMID34771424
PMCPMC8582354
OpenAlexW3206292073

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.