Evidence map›Paper›PMID 34771258›Full record

ArticlePolymers2021

Antibacterial and Hemocompatible pH-Responsive Hydrogel for Skin Wound Healing Application: In Vitro Drug Release.

Muhammad Umar Aslam Khan, Saiful Izwan Abd Razaq, Hassan Mehboob, Sarish Rehman, Wafa Shamsan Al-Arjan, Rashid Amin

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 128 citations in OpenAlex.

  1. Trial
  2. Design of a Gelatin/Carboxymethyl Cellulose Hydrogel Containing Myrtus Communis Extract with Anti-inflammatory Capabilities for Accelerated Wound Healing; in Vitro and in Vivo Study.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Gels (Basel, Switzerland) · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Enhanced Wound Healing withCurrent pharmaceutical design · 2025
    Article
  18. Article
  19. Article
  20. Development of alginate/chitosan hydrogel loaded with obestatin and evaluation of collagen type I, III, VEGF and TGF-βSkin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 5 countries.

Muhammad Umar Aslam KhanBioInspired Device and Tissue Engineering Research Group, School of Biomedical Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia, Skudai 81300, Johor, Malaysia.ORCID 0000-0002-2724-1336
Saiful Izwan Abd RazaqInstitute of Personalized Medicine, School of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University (SJTU),1954 Huashan Road, Shanghai 200030, China.ORCID 0000-0001-7477-0284
Hassan MehboobDepartment of Engineering Management, College of Engineering, Prince Sultan University, Rafha Street, P.O. Box 66833, Riyadh 11586, Saudi Arabia.ORCID 0000-0003-1184-1326
Sarish RehmanChemistry Department, McGill University, 801 Sherbrooke St. W, Montreal, QC H3A0G4, Canada.
Wafa Shamsan Al-ArjanDepartment of Chemistry, College of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
Rashid AminDepartment of Biology, College of Sciences, University of Hafr Al Batin, Hafar Al-Batin 39524, Saudi Arabia.
King Faisal University · SAMcGill University · CAPrince Sultan University · SAQuaid-i-Azam University · PKShanghai Jiao Tong University · CNUniversity of Hafr Al-Batin · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The treatment of successive skin wounds necessitates meticulous medical procedures. In the care and treatment of skin wounds, hydrogels produced from natural polymers with controlled drug release play a crucial role. Arabinoxylan is a well-known and widely available biological macromolecule. We produced various formulations of blended composite hydrogels (BCHs) from arabinoxylan (ARX), carrageenan (CG), and reduced graphene oxide (rGO) using and cross-linked them with an optimal amount of tetraethyl orthosilicate (TEOS). The structural, morphological, and mechanical behavior of the BCHs samples were determined using Fourier-transform infrared spectroscopy (FT-IR), Scanning electron microscope (SEM), mechanical testing, and wetting, respectively. The swelling and degradation assays were performed in phosphate-buffered saline (PBS) solution and aqueous media. Maximum swelling was observed at pH 7 and the least swelling in basic pH regions. All composite hydrogels were found to be hemocompatible. In vitro, silver sulfadiazine release profile in PBS solution was analyzed via the Franz diffusion method, and maximum drug release (87.9%) was observed in 48 h. The drug release kinetics was studied against different mathematical models (zero-order, first-order, Higuchi, Hixson-Crowell, Korsmeyer-Peppas, and Baker-Lonsdale models) and compared their regression coefficient (R

Indexed as

antibacterialbiomaterialsbiopolymerscontrolled drug releasehemocompatibilitykinetics studieswound dressing

Identifiers

PMID34771258
PMCPMC8588096
OpenAlexW3210304158

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.