Evidence map›Paper›PMID 34771159›Full record

ArticleMolecules (Basel, Switzerland)2021

Attenuative Effects of Fluoxetine and

Karema Abu-Elfotuh, Ghada M Ragab, Ahmad Salahuddin, Lubna Jamil, Ekram Nemr Abd Al Haleem

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Targeting Ferroptosis/Nrf2 Pathway Ameliorates AlClInternational journal of molecular sciences · 2025
    Article
  3. Article
  4. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Karema Abu-ElfotuhDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Cairo 11754, Egypt.
Ghada M RagabDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Misr University for Science and Technology, Giza 12585, Egypt.
Ahmad SalahuddinDepartment of Biochemistry, Faculty of Pharmacy, Damanhour University, Damanhour 22511, Egypt.ORCID 0000-0002-7382-4284
Lubna JamilDepartment of Histology, Faculty of Medicine, October 6 University, Giza 12585, Egypt.
Ekram Nemr Abd Al HaleemDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Cairo 11754, Egypt.ORCID 0000-0001-8938-9013
Al-Azhar University · EGDamanhour University · EGMisr University for Science and Technology · EGOctober 6 University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlzheimer's disease (AD) is a chronic neurological illness that causes considerable cognitive impairment. Hepatic and renal dysfunction may worsen AD by disrupting β-amyloid homeostasis at the periphery and by causing metabolic dysfunction. Wheatgrass (Triticum aestivum) has been shown to have antioxidant and anti-inflammatory properties. This work aims to study the effect of aluminum on neuronal cells, its consequences on the liver and kidneys, and the possible role of fluoxetine and wheatgrass juice in attenuating these pathological conditions.

methodRats were divided into five groups. Control, AD (AlCl

conclusionsAlCl

conclusionFluoxetine and wheatgrass combination demonstrated a more significant neuroprotective impact in treating AD than fluoxetine alone and has protective effects on liver and kidney tissues.

Indexed as

Aluminum ChlorideAlzheimer DiseaseAnimalsFluoxetineKidneyLiverMaleNeuroprotective AgentsRatsRats, WistarTriticumAluminum ChlorideFluoxetineNeuroprotective AgentsAlzheimer’sBDNFGSK-3βhepatotoxicitynephrotoxicitytau proteinTriticum aestivumβ-amyloidβ–catenin

Identifiers

PMID34771159
PMCPMC8588015
OpenAlexW3213901767

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.