Evidence map›Paper›PMID 34771137›Full record

ArticleMolecules (Basel, Switzerland)2021

Interaction Study between ESIPT Fluorescent Lipophile-Based Benzazoles and BSA.

Thais Kroetz, Pablo Andrei Nogara, Fabiano da Silveira Santos, Lilian Camargo da Luz, Viktor Saraiva Câmara, João Batista Teixeira da Rocha, Alexandre Gonçalves Dal-Bó, Fabiano Severo Rodembusch

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Thais KroetzGrupo de Pesquisa em Fotoquímica Orgânica Aplicada, Instituto de Química, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves 9500, Bairro Agronomia, Porto Alegre 91501-970, CEP, Brazil.
Pablo Andrei NogaraDepartamento de Bioquímica e Biologia Molecular, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria-UFSM, Santa Maria 97105-900, RS, Brazil.ORCID 0000-0002-9133-6102
Fabiano da Silveira SantosGrupo de Pesquisa em Fotoquímica Orgânica Aplicada, Instituto de Química, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves 9500, Bairro Agronomia, Porto Alegre 91501-970, CEP, Brazil.
Lilian Camargo da LuzGrupo de Pesquisa em Fotoquímica Orgânica Aplicada, Instituto de Química, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves 9500, Bairro Agronomia, Porto Alegre 91501-970, CEP, Brazil.
Viktor Saraiva CâmaraGrupo de Pesquisa em Fotoquímica Orgânica Aplicada, Instituto de Química, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves 9500, Bairro Agronomia, Porto Alegre 91501-970, CEP, Brazil.
João Batista Teixeira da RochaDepartamento de Bioquímica e Biologia Molecular, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria-UFSM, Santa Maria 97105-900, RS, Brazil.
Alexandre Gonçalves Dal-BóPrograma de Pós-Graduação em Ciência e Engenharia de Materiais, Universidade do Extremo Sul Catarinense (UNESC), Av. Universitária 1105, Criciúma 88806-000, CEP, Brazil.ORCID 0000-0002-2289-395X
Fabiano Severo RodembuschGrupo de Pesquisa em Fotoquímica Orgânica Aplicada, Instituto de Química, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves 9500, Bairro Agronomia, Porto Alegre 91501-970, CEP, Brazil.ORCID 0000-0001-6528-2318

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior Finance Code 001Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul 17/2551-0000968-1National Council for Scientific and Technological Development 305954/2019-9 and 154885/2018-5
6 · The paper itself

Abstract

In this study, the interactions of ESIPT fluorescent lipophile-based benzazoles with bovine serum albumin (BSA) were studied and their binding affinity was evaluated. In phosphate-buffered saline (PBS) solution these compounds produce absorption maxima in the UV region and a main fluorescence emission with a large Stokes shift in the blue-green regions due to a proton transfer process in the excited state. The interactions of the benzazoles with BSA were studied using UV-Vis absorption and steady-state fluorescence spectroscopy. The observed spectral quenching of BSA indicates that these compounds could bind to BSA through a strong binding affinity afforded by a static quenching mechanism (K

Indexed as

AnimalsBenzothiazolesCattleFluorescenceLipidsMolecular StructureSerum Albumin, BovineSpectrometry, FluorescenceSpectrophotometry, UltravioletBenzothiazolesLipidsSerum Albumin, Bovinebenzazolesbovine serum albuminfluorescence quenchingmolecular dockingproton transfer

Identifiers

PMID34771137
PMCPMC8586955

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.