Evidence map›Paper›PMID 34771089›Full record

ArticleMolecules (Basel, Switzerland)2021

Labdane Diterpenoids from

Valeria Iobbi, Paola Brun, Giulia Bernabé, Roméo Arago Dougué Kentsop, Giuliana Donadio, Barbara Ruffoni, Paola Fossa, Angela Bisio, Nunziatina De Tommasi

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Anti-Biofilm Activity of Carnosic Acid fromPlants (Basel, Switzerland) · 2023
    Article
  4. Article
  5. Review
  6. Review
  7. The bioactivities of sclareol: A mini review.Frontiers in pharmacology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Valeria IobbiDepartment of Pharmacy, University of Genova, Viale Cembrano 4, 16148 Genova, Italy.
Paola BrunDepartment of Molecular Medicine, University of Padova, Via Gabelli 63, 35121 Padova, Italy.ORCID 0000-0002-3279-9000
Giulia BernabéDepartment of Molecular Medicine, University of Padova, Via Gabelli 63, 35121 Padova, Italy.
Roméo Arago Dougué KentsopDepartment of Pharmacy, University of Genova, Viale Cembrano 4, 16148 Genova, Italy.ORCID 0000-0002-3389-4472
Giuliana DonadioDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084 Salerno, Italy.
Barbara RuffoniConsiglio per la Ricerca e la Sperimentazione in Agricoltura-CREA Centro di ricerca Orticoltura e Florovivaismo, 18038 San Remo, Italy.
Paola FossaDepartment of Pharmacy, University of Genova, Viale Cembrano 4, 16148 Genova, Italy.ORCID 0000-0001-9386-0445
Angela BisioDepartment of Pharmacy, University of Genova, Viale Cembrano 4, 16148 Genova, Italy.ORCID 0000-0002-7559-7732
Nunziatina De TommasiDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084 Salerno, Italy.
University of Genoa · ITCentro di Ricerca per l’Orticoltura · ITUniversity of Padua · ITUniversity of Salerno · IT

Funding

EU INTERREG V ALCOTRA (2014 - 2020) PITER Project "ALPIMED INNOV" n° 4073
6 · The paper itself

Abstract

Quorum-sensing (QS) is a regulatory mechanism in bacterial communication, important for pathogenesis control. The search for small molecules active as quorum-sensing inhibitors (QSI) that can synergize with antibiotics is considered a good strategy to counteract the problem of antibiotic resistance. Here the antimicrobial labdane diterpenoids sclareol (

Indexed as

Anti-Bacterial AgentsClindamycinDose-Response Relationship, DrugMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMolecular ConformationMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructurePhytochemicalsPlant ExtractsQuorum SensingSalviaStructure-Activity RelationshipAnti-Bacterial AgentsClindamycinPhytochemicalsPlant Extractscallusmanoolmolecular dockingpentacyclic triterpenoidsquorum sensing inhibitorsSalvia tingitanasclareol

Identifiers

PMID34771089
PMCPMC8587691
OpenAlexW3212457752

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.