Interaction of Carrier Protein with Potential Metallic Drug Candidate

Sabiha Parveen, Mohd Sajid Ali, Hamad A Al-Lohedan, Sartaj Tabassum

Open access · goldAbstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.2field-weighted citation impact, top 50% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Sabiha ParveenDepartment of Chemistry, Aligarh Muslim University, Aligarh 202002, India.ORCID 0000-0002-3953-3248

Mohd Sajid AliDepartment of Chemistry, College of Sciences, King Saud University, Riyadh 11451, Saudi Arabia.

Hamad A Al-LohedanDepartment of Chemistry, College of Sciences, King Saud University, Riyadh 11451, Saudi Arabia.

Sartaj TabassumDepartment of Chemistry, Aligarh Muslim University, Aligarh 202002, India.ORCID 0000-0002-5301-898X

Aligarh Muslim University · INKing Saud University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lysozyme is often used as a model protein to study interaction with drug molecules and to understand biological processes which help in illuminating the therapeutic effectiveness of the drug. In the present work, in vitro interaction studies of 1-{(2-hydroxyethyl)amino}-2-amino-1,2-dideoxy-d-glucose triphenyl tin (IV) (GATPT) complex with lysozyme were carried out by employing various biophysical methods such as absorption, fluorescence, and circular dichroism (CD) spectroscopies. The experimental results revealed efficient binding affinity of GATPT with lysozyme with intrinsic binding (K

Indexed as

Molecular Docking SimulationMolecular Dynamics SimulationSpectrum AnalysisAminoglycosidesBinding SitesCarrier ProteinsDNAKineticsMolecular ConformationMuramidaseOrganometallic CompoundsOrganotin CompoundsProtein BindingThermodynamics1-((2-hydroxyethyl)amino)-2-amino-1,2-dideoxyglucose triphenyltin(IV)AminoglycosidesCarrier ProteinsDNAMuramidaseOrganometallic CompoundsOrganotin Compoundsinteraction studieslysozymemolecular dockingorganotinthermodynamics

Identifiers

PMID34771048

DOI10.3390/molecules26216641

PMCPMC8587009

OpenAlexW3210498714

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.