Evidence map›Paper›PMID 34770969›Full record

ArticleMolecules (Basel, Switzerland)2021

Naturally Available Flavonoid Aglycones as Potential Antiviral Drug Candidates against SARS-CoV-2.

Ahmed A Al-Karmalawy, Mai M Farid, Ahmed Mostafa, Alia Y Ragheb, Sara H Mahmoud, Mahmoud Shehata, Noura M Abo Shama, Mohamed GabAllah, Gomaa Mostafa-Hedeab, Mona M Marzouk

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  9. Biological evaluation, docking studies, andJournal of enzyme inhibition and medicinal chemistry · 2023
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  16. Cholinesterase Inhibitors from an Endophytic FungusMolecules (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ahmed A Al-KarmalawyDepartment of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta 34518, Egypt.ORCID 0000-0002-8173-6073
Mai M FaridDepartment of Phytochemistry and Plant Systematics, National Research Centre, 33 El Bohouth St., Dokki, Giza 12622, Egypt.
Ahmed MostafaCenter of Scientific Excellence for Influenza Virus, Environmental Research Division, National Research Centre, 33 El Bohouth St., Dokki, Giza 12622, Egypt.ORCID 0000-0002-2878-5714
Alia Y RaghebDepartment of Phytochemistry and Plant Systematics, National Research Centre, 33 El Bohouth St., Dokki, Giza 12622, Egypt.
Sara H MahmoudCenter of Scientific Excellence for Influenza Virus, Environmental Research Division, National Research Centre, 33 El Bohouth St., Dokki, Giza 12622, Egypt.
Mahmoud ShehataCenter of Scientific Excellence for Influenza Virus, Environmental Research Division, National Research Centre, 33 El Bohouth St., Dokki, Giza 12622, Egypt.ORCID 0000-0001-7556-9398
Noura M Abo ShamaCenter of Scientific Excellence for Influenza Virus, Environmental Research Division, National Research Centre, 33 El Bohouth St., Dokki, Giza 12622, Egypt.
Mohamed GabAllahCenter of Scientific Excellence for Influenza Virus, Environmental Research Division, National Research Centre, 33 El Bohouth St., Dokki, Giza 12622, Egypt.
Gomaa Mostafa-HedeabPharmacology Department & Health Research Unit, Medical College, Jouf University, Skaka 11564, Saudi Arabia.
Mona M MarzoukDepartment of Phytochemistry and Plant Systematics, National Research Centre, 33 El Bohouth St., Dokki, Giza 12622, Egypt.ORCID 0000-0003-3176-1470

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Flavonoids are important secondary plant metabolites that have been studied for a long time for their therapeutic potential in inflammatory diseases because of their cytokine-modulatory effects. Five flavonoid aglycones were isolated and identified from the hydrolyzed aqueous methanol extracts of

Indexed as

AnimalsAntiviral AgentsBrassicaceaeChlorocebus aethiopsChromonesCoronavirus 3C ProteasesCOVID-19 Drug TreatmentDrug DiscoveryFlavonesFlavonoidsHumansMolecular Docking SimulationMolecular Dynamics SimulationPlant ExtractsProtease InhibitorsQuercetinAntiviral AgentsChromonesCoronavirus 3C ProteasesFlavonesFlavonoidsgardenin BhispidulinpectolinarigeninPlant ExtractsProtease InhibitorsQuercetintangeretintaxifolinAnastatica hierochunticaCitrus reticulateflavonoid aglyconesin vitro screeningKickxia aegyptiacamolecular dockingSARS-CoV-2

Identifiers

PMID34770969
PMCPMC8587465

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.