Evidence map›Paper›PMID 34770920›Full record

ArticleMolecules (Basel, Switzerland)2021

X-ray Structure Determination, Antioxidant Voltammetry Studies of Butein and 2',4'-Dihydroxy-3,4-dimethoxychalcone. Computational Studies of 4 Structurally Related 2',4'-diOH Chalcones to Examine Their Antimalarial Activity by Binding to Falcipain-2.

Ijeoma Okoye, Sandra Yu, Francesco Caruso, Miriam Rossi

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Ginger (International journal of molecular sciences · 2025
    Article
  3. Article
  4. Antioxidant Scavenging of the Superoxide Radical by Yerba Mate (International journal of molecular sciences · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ijeoma OkoyeDepartment of Chemistry, Vassar College, Poughkeepsie, NY 12604, USA.ORCID 0000-0001-5299-6135
Sandra YuDepartment of Chemistry, Vassar College, Poughkeepsie, NY 12604, USA.ORCID 0000-0003-1827-9794
Francesco CarusoDepartment of Chemistry, Vassar College, Poughkeepsie, NY 12604, USA.
Miriam RossiDepartment of Chemistry, Vassar College, Poughkeepsie, NY 12604, USA.ORCID 0000-0001-9609-474X
Vassar College · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malaria is a huge global health burden with resistance to currently available medicines resulting in the search for newer antimalarial compounds from traditional medicinal plants in malaria-endemic regions. Previous studies on two chalcones, homobutein and 5-prenylbutein, present in

Indexed as

AntimalarialsAntioxidantsBinding SitesChalconesCysteine EndopeptidasesDose-Response Relationship, DrugMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructureProtein BindingStructure-Activity Relationship3,4-dimethoxychalconeAntimalarialsAntioxidantsChalconesCysteine Endopeptidasesfalcipain 2antioxidantbuteinchalconefalcipain-2superoxide

Identifiers

PMID34770920
PMCPMC8588236
OpenAlexW3208629499

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.